{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:10:01Z","timestamp":1785305401744,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diagnosis of asthma and chronic obstructive pulmonary disease (COPD) becomes difficult in a primary healthcare center due to ambiguous interpretation of spirometry and lack of facility to access established biomarkers. While routine hematological indices are easily available and accessible. The study aimed to evaluate the role of different hemogram indexes in males in COPD, asthma, and healthy smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Lung function tests and complete blood count (CBC) were done for 50 male subjects each from asthma, COPD, and healthy smokers. Multivariate analysis (MVA) was performed on blood indices data set. Receiver operating characteristic (ROC) curve was plotted to observe the performance of indexes. Pearson correlation was used to establish association between the lung function and blood indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the indices were elevated in COPD. Whereas, asthma patients showed a significant increase in eosinophil basophil ratio (EBR), lymphocyte\u2010monocyte ratio (LMR), and mean platelet volume\u2010platelet count ratio (MPR). Orthogonal (O)\u2010 Partial Least\u2010Squares Discriminant Analysis (PLSDA) and variable importance in projection (VIP) score established EBR, neutrophil\u2010lymphocyte ratio (NLR) and LMR, as discriminants for asthma. Whereas, Systemic Inflammatory Response Index (SIRI), NLR and EBR were the key variables for COPD. NLR (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and SIRI (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.71, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were found to be negatively correlated with forced expiratory volume in 1\u2009s (FEV1) percentage of the predicted value (%pred) in asthma and COPD, respectively. EBR showed the sensitivity and specificity of 96% and 86% respectively in asthma. NLR was having sensitivity of 82% and 90% specificity in COPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study in males shows routine hematological indices as being cost\u2010effective, feasible, and seem to have tremendous potential as screening markers among chronic respiratory diseases in a primary healthcare center.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14264","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:29:51Z","timestamp":1710570591000},"page":"627-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic insights from chemometric analysis of hemogram inflammatory indexes in male smokers with and without asthma or chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-8399","authenticated-orcid":false,"given":"Brajesh","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiti","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Public Health Kalinga Institute of Industrial Technology University  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Pundit","sequence":"additional","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00164\u20102019"},{"issue":"7","key":"e_1_2_10_4_1","first-page":"34","article-title":"A review of the utility and cost effectiveness of monitoring fractional exhaled nitric oxide (FeNO) in asthma management","volume":"27","author":"Arnold RJ","year":"2018","journal-title":"Managed Care (Langhorne, Pa)"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8841002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.03.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"Eraslan DoganayG CirikMO.Are neutrophil\u2010lymphocyte platelet\u2010lymphocyte and monocyte\u2010lymphocyte ratios prognostic indicators in patients with chronic obstructive pulmonary disease in intensive care units? 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