{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:57:04Z","timestamp":1769921824170,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100022298","name":"Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCRD108\u201073"],"award-info":[{"award-number":["TCRD108\u201073"]}],"id":[{"id":"10.13039\/501100022298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Platelet transfusion is a standard treatment to prevent bleeding in patients with hematological malignancies. Although transfusions can improve platelet count, their impact on platelet function remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted flow cytometry to assess platelet function before and after transfusion and performed subgroup analyses to examine differences based on blood type, corrected count increment (CCI), and platelet microparticles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 50 patients who received prophylactic platelet transfusion were enrolled. CD42b expression increased, whereas CD41 expression decreased after transfusion. Apheresis platelets exhibited the lowest expression of PAC\u20101 and P\u2010selectin when exposed to agonist stimulations. PAC\u20101 expression increased under high adenosine diphosphate (ADP) stimulation, while P\u2010selectin expression increased under both high ADP and thrombin receptor\u2010activating peptide stimulation. In the subgroup analysis, patients with a CCI &gt;4500 and those with the same blood types exhibited a more significant increase in PAC\u20101 and P\u2010selectin expression under agonist stimulation. When comparing apheresis platelets collected on different days, only the percentage of platelet\u2010derived microparticles showed a significant\u00a0increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic transfusion improved platelet function. Platelet function significantly improved in patients with a CCI &gt;4500, those with the same blood types as that of apheresis platelets, or those with platelet\u2010derived microparticle levels &lt;4.7%. No significant improvement in platelet function was noted after the transfusion of different blood types with acceptable compatibility or the transfusion of incompatible blood types. Our results suggest that transfusing platelets with the same blood type remains the optimal choice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14283","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T08:28:43Z","timestamp":1714379323000},"page":"722-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improving platelet function following prophylactic platelet transfusion in patients with hematological malignancies"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-9194","authenticated-orcid":false,"given":"Yi\u2010Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"College of Medicine Tzu\u2010Chi University  Hualien Taiwan"},{"name":"Ph.D. Program in Pharmacology and Toxicology Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Lung","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Department of Clinical Pathology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Chao","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"College of Medicine Tzu\u2010Chi University  Hualien 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