{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:53:05Z","timestamp":1781855585030,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The monitoring of unfractionated heparin (UFH) by anti\u2010factor Xa activity (AXA) is commonly used to ensure effective anticoagulation and prevent bleeding risk. However, in patients previously treated with an anti\u2010Xa direct oral anticoagulant (DOAC) switching to UFH therapy, there is a risk of interference that may lead to inappropriate anticoagulation. The first objective of this study was to validate DOAC\u2010Remove to remove DOAC for measuring UFH specific AXA. The second objective was to assess the length of DOAC interference on UFH monitoring and to identify potential predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This monocentric retrospective study included all patients admitted from April 2019 to April 2021 previously treated with anti\u2010Xa DOAC, and for whom an interference on UFH monitoring was suspected. Interference was defined as a difference in the AXA measured before and after using DOAC\u2010Remove &gt;2.8\u2010fold standard deviation of the method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Removal with DOAC\u2010Remove was specific of DOAC (apixaban\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942, rivaroxaban\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941, UFH\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) and sufficient to avoid interference on UFH AXA measurement. The exact interference length was 6.0\u2009days [IQR 3.0\u201311.0] for apixaban (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) and 4.5\u2009days [IQR 2.0\u20135.8] for rivaroxaban (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920). Among the 89 patients sorted based on an interference length \u2264 or &gt;3\u2009days, 74 (83.1%) presented an interference greater than 3\u2009days. Correlations were observed with age for apixaban and creatinine for rivaroxaban.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that DOAC\u2010Remove could be of high interest in patients receiving UFH previously treated with an anti\u2010Xa DOAC even if DOAC was stopped for more than 3\u2009days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.14321","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T01:58:05Z","timestamp":1716861485000},"page":"953-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>DOAC\u2010Remove<\/scp>\n                    to counteract the interference of\n                    <scp>anti\u2010Xa<\/scp>\n                    oral anticoagulants on the monitoring of heparin"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-3844","authenticated-orcid":false,"given":"Sophie","family":"Melicine","sequence":"first","affiliation":[{"name":"Hematology Department, AP\u2010HP.CUP Georges Pompidou European Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Habay","sequence":"additional","affiliation":[{"name":"Hematology Department, AP\u2010HP.CUP Georges Pompidou European Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiame","family":"Ghammad","sequence":"additional","affiliation":[{"name":"Hematology Department, AP\u2010HP.CUP Georges Pompidou European Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Hematology Department, AP\u2010HP.CUP Georges Pompidou European Hospital  Paris 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