{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:11Z","timestamp":1747185431443,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Specific assays of plasma rivaroxaban level are not always readily available with short turnaround time, which hamper the management of urgent clinical situations. In this study, we aimed to build a predictive formula of plasma rivaroxaban levels from international normalized ratio (INR) value and validated in real world clinical situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010four patients who were taking rivaroxaban participated in the study. Patients were randomized into testing cohort and validation cohorts. The prediction formula was built from the testing cohort and then validated in validation cohort. The predictive performance was further validated on real\u2010world clinical requests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The root mean square error (RMSE) of the predictive formula for the testing and validation cohorts were 61.81 and 69.32\u2009ng\/mL, respectively. The sensitivity and specificity for the formula to predict the threshold plasma rivaroxaban level of 75\u2009ng\/mL were 95% (95% CI: 85.4%\u2013100%) and 87.5% (95% CI: 71.3%\u2013100%), respectively, in real\u2010world clinical situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plasma rivaroxaban level of threshold level of 75\u2009ng\/mL can be calculated from prediction formula by INR value with satisfactory accuracy and it can be used to guide the decision for reversal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14347","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:49:31Z","timestamp":1721263771000},"page":"1101-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of international normalized ratio\u2010derived formula to predict plasma rivaroxaban level\u2014Validation study and real\u2010world 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