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Platelet recovery (PR) following HSCT is assessed by monitoring platelet count (PC). Immature platelet fraction (IPF) is a research parameter offered by Sysmex\u00ae on XN series analyzers, enabling rapid diagnostic orientation in the event of thrombocytopenia. It has also been described as a predictive factor for PR after chemotherapy or HSCT, and thresholds have been proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The objective of this study was to assess the predictive capability of IPF for PR in a prospective cohort of patients undergoing HSCT and to evaluate its utility in guiding platelet transfusion decision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An optimized A\u2010IPF (absolute number of IPF) threshold of 2.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was predictive of a PC greater than 50\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L at day 30 with a sensitivity of 78.9%, specificity of 78.6%, positive predictive value (PPV) of 83.3% and negative predictive value (NPV) of 73.3%. We were able to distinguish patients recovering PC before day 15 with an earlier %IPF peak, greater IPF recovery kinetics and faster neutrophil recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A\u2010IPF shows promise as a predictor of PR following HSCT. A multicenter study could help confirm both A\u2010IPF and %IPF (IPF) clinical utility before it is made available to clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14358","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T22:37:51Z","timestamp":1725489471000},"page":"41-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the immature platelet fraction as a predictive marker of bone marrow regeneration after hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"47","author":[{"given":"K\u00e9lian","family":"Steibel","sequence":"first","affiliation":[{"name":"Laboratory of Hematology Amiens\u2010Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Joris","sequence":"additional","affiliation":[{"name":"Department of Hematology Amiens\u2010Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Clichet","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Saint Louis hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Charbonnier","sequence":"additional","affiliation":[{"name":"Department of Hematology Amiens\u2010Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Desoutter","sequence":"additional","affiliation":[{"name":"Laboratory of Histocompatibility Amiens\u2010Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Marolleau","sequence":"additional","affiliation":[{"name":"Department of Hematology Amiens\u2010Picardie University Hospital  Amiens France"},{"name":"UR 4666 HEMATIM Universit\u00e9 Picardie Jules Verne  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Gar\u00e7on","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Amiens\u2010Picardie University Hospital  Amiens France"},{"name":"UR 4666 HEMATIM Universit\u00e9 Picardie Jules Verne  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-5491","authenticated-orcid":false,"given":"Thomas","family":"Boyer","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Amiens\u2010Picardie University Hospital  Amiens France"},{"name":"UR 4666 HEMATIM Universit\u00e9 Picardie Jules Verne  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.1969.tb01366.x"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"996","article-title":"In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation","volume":"23","author":"Ault KA","year":"1995","journal-title":"Exp Hematol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102141.2000.01939.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100609.1999.tb01884.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.1.116.116"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100609.1995.tb00209.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102257.2004.00596.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102012\u2010200930"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPUAGGB4URL5XO"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.09.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2010.30.5.451"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn047"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2004.04987.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.04.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u2010553X.2007.00993.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12319"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.09.031"},{"key":"e_1_2_8_19_1","unstructured":"CIBMTR.Getting Started\u2014Forms Instruction Manual\u20131. 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