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However, pregnancy complications characterized by systemic inflammatory response syndrome may consume fibrinogen, resulting in elevated D\u2010dimer levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study is based on a total of 16\u2009768 pregnant women who delivered between December 1, 2013, and December 1, 2018, to study fibrinogen and D\u2010dimer changes during gestation under normal and multiples of pathogenic states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Compared with nonpregnant women (3.04[3.02\u20133.08]), pregnant women depicted higher fibrinogen levels throughout gestation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the uncomplicated group, fibrinogen levels increased throughout the first (3.28[3.26\u20133.29]), second (4.04[4.01\u20134.07]), and third trimesters (4.40[4.38\u20134.41]) but dropped at delivery (4.30[4.28\u20134.31]), similar to the changing pattern of the pregnancy\u2010related complication group and pre\u2010existing disorder group. Women with pregnancy\u2010related complications showed significantly higher mean fibrinogen levels throughout gestation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), except for placental abruption, where, it decreased from the third trimester and was lower than that of uncomplicated pregnancies (3.89[3.60\u20134.17] vs. 4.40 [4.38\u20134.41], <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Among uncomplicated pregnancies, D\u2010dimer grew rapidly throughout the first trimester (0.09[0.06\u20130.15]), second trimester (0.28[0.19\u20130.40]), third trimester (0.51[0.36\u20130.78]), and delivery (0.70[0.47\u20131.03]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with pregnancy\u2010related complications and pre\u2010existing disorders shared similar changing patterns; however, the D\u2010dimer of women with placenta accreta presented higher levels than those with uncomplicated pregnancies since the first trimester. We concluded that fibrinogen levels are expected to increase steadily, but in patients with placental abruption, fibrinogen levels dropped during the third trimester. D\u2010dimer levels typically rise consistently throughout pregnancy, yet in patients with placenta accreta, they show abnormal elevation since an early stage of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14382","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T01:56:48Z","timestamp":1732672608000},"page":"156-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Fibrinogen and D\u2010Dimer During Complicated and Uncomplicated Pregnancy"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-9599","authenticated-orcid":false,"given":"Chen","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Peking University Third Hospital  Beijing China"},{"name":"Department of Laboratory Medicine Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-1635","authenticated-orcid":false,"given":"Yang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wei","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Peking University Third Hospital  Beijing China"},{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Laboratory Medicine Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2009.11.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13741-021-00225-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev374"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.06.027"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.05.021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-1220"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05429-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.545432"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2010"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"34","article-title":"The Pathophysiology of Hypercoagulability and Infertility","volume":"39","author":"Malinowski A. 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