{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:10:17Z","timestamp":1792627817934,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A wide variety of laboratory hemostasis tests is available, but the majority is plasma\u2010based, static and unable to assess platelet function and fibrin formation simultaneously. The Total Thrombus\u2010Formation Analysis System (T\u2010TAS) is a microchip\u2010based flow chamber system that simulates in\u00a0vivo conditions for evaluating whole blood thrombogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>A comprehensive overview of its applicability in different thrombosis and hemostasis related clinical situations is lacking and therefore this scoping review was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; methods<\/jats:title>\n                    <jats:p>A literature search was done using the electronic databases PubMed, Scopus and Embase on January 7, 2024. Original studies assessing the usefulness of the T\u2010TAS in thrombosis and hemostasis related clinical situations were eligible for this scoping review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 28 studies were included; six studies investigating the role of the T\u2010TAS in congenital bleeding disorders, five studies using the T\u2010TAS to assess 1\u2010year bleeding risk in patients on antiplatelet or anticoagulant medications, four studies investigating the effects of thrombocytopenia and hemodialysis on thrombus formation as measured by the T\u2010TAS, 11 studies testing the applicability of the T\u2010TAS in the monitoring of anticoagulant and antiplatelet therapies and eventually two studies on the ability of the T\u2010TAS to assess the thrombogenicity in different disease entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion &amp; conclusion<\/jats:title>\n                    <jats:p>The T\u2010TAS method is an interesting technology that mimics the complex biological coagulation process using shear forces, creating a \u201cblood vessel component on a chip\u201d. More research is needed, but it could eventually function as a screening test for platelet function and coagulation. Moreover, it could be used to detect the presence of anticoagulant and\/or antiplatelet medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.14403","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T03:12:59Z","timestamp":1733886779000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Utility of Total Thrombus\u2010Formation Analysis System (T\u2010\n                    <scp>TAS<\/scp>\n                    ) in the Thrombosis and Hemostasis Field: A Scoping Review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-0156","authenticated-orcid":false,"given":"H.","family":"Mansouritorghabeh","sequence":"first","affiliation":[{"name":"Central Diagnostic Laboratories, Ghaem Hospital Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Internal Medicine, Division of Thrombosis 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