{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:15:28Z","timestamp":1789215328708,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272401"],"award-info":[{"award-number":["82272401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aimed to identify additional predictors of severe fever with thrombocytopenia syndrome (SFTS), which has a significantly increasing global incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 95 patients with SFTS and 30 healthy individuals. Complete blood count with differential was performed using Sysmex XN 9000 and Mindray BC\u20106800 Plus analyzers. Extended leukocyte cell population data (CPD) parameters were acquired using a Mindray BC\u20106800 Plus analyzer. Peripheral smears were identified, and SFTS virus (SFTSV) RNA was detected using real\u2010time reverse transcription polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 95 patients with SFTS at admission, 75.8% (72\/95) presented leukopenia and 96.8% (92\/95) thrombocytopenia with SFTS. Neutrophil left shift and smudge cells (32.4\/WBC\u2009\u00b1\u200928.2\/WBC) were observed 100% (57\/57) on the blood smear. Only 21.1% (21\/57) of the reactive lymphocytes were &gt;\u20095% (3.24%\u2009\u00b1\u20093.35%). Moreover, 33.3% (19\/57) of apoptotic lymphocytes and 8.8% (5\/57) of nucleated red blood cells were present. Furthermore, 78.9% (45\/57) of reactive plasmacytoid lymphocytes increased 3\u20135\u2009days after admission and 61.1% (11\/18) of the patients who died presented with dust blue inclusions in the neutrophils. Compared to the control group, Neu\u2010Y and all lymphocyte and monocyte CPD parameters were significantly higher in all SFTS groups. Compared to the surviving patients with SFTS, Lym\u2010Y in Group 2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was significantly lower, but Neu\u2010Y and Mon\u2010Z in Group 3 were higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in the death group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cell count, peripheral blood morphology, and CPD parameters described in this study had a strong prompting effect on SFTSV infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14414","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:53:36Z","timestamp":1734515616000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CBC<\/scp> With Differential and Cell Population Data in Prediction of Fever With Thrombocytopenia Syndrome"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-2452","authenticated-orcid":false,"given":"Lixia","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing People's Republic of China"},{"name":"Branch of National Clinical Research Center for Laboratory Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing People's Republic of China"},{"name":"Branch of National Clinical Research Center for Laboratory Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing People's Republic of China"},{"name":"Branch of National Clinical Research Center for Laboratory Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Mu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing People's Republic of China"},{"name":"Branch of National Clinical Research Center for Laboratory Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Pan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing People's Republic of China"},{"name":"Branch of National Clinical Research Center for Laboratory Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175592","article-title":"Seroprevalence of Severe Fever With Thrombocytopenia Syndrome Virus in China: A Systematic Review and Meta\u2010Analysis","volume":"12","author":"Li P.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02403-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.07.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6727184"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.02.017"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1348836"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13071213"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.14193"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2021-1309"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2022-0713"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5639"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.14057"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1119"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.03.017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12327"},{"key":"e_1_2_12_17_1","volume-title":"Color Atlas of Hematology: An Illustrated Field Guide Based on Proficiency Testing","author":"Glassy E. 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