{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:40:01Z","timestamp":1747291201294,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The causes of nonsyndromic platelet storage pool disease are still unclear, and whether they are of genetic or acquired origin remains to be defined. The study aimed to describe the characteristics and natural history of this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This mostly retrospective cohort enrolled adults presenting with bleeding from platelet dysfunction. Platelet glycoprotein defects, von Willebrand disease, syndromic inherited platelet disorders and known acquired platelet dysfunctions were excluded. Available patients were retested by lumiaggregometry (Chrono\u2010Log) over 1\u2009year after the initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a total of 56 patients; 91% female, with a median diagnostic age of 28\u2009years (interquartile range [IQR]: 24.5\u201338.5). The subnormal responses to ADP, epinephrine, collagen, and arachidonate were found in 91%, 82%, 55%, and 34%, respectively. Nineteen patients had von Willebrand factor levels measured. Twenty\u2010three subjects underwent repeat tests. Twenty\u2010one of them were female (91%), with a median age and follow\u2010up time of 37\u2009years (IQR: 28\u201355) and 6\u2009years (IQR: 3\u201312), respectively. Median ISTH\u2010BAT bleeding scores at diagnosis and follow\u2010up were 5 (IQR: 3\u20138) and 1 (IQR: 0\u20132), respectively. The common abnormalities were reduced responses to ADP combined with other agonists (83%). Twelve (52%) and five (22%) showed complete and partial platelet function recovery, respectively. None of the partial and non\u2010recovery groups had a bleeding score over 4 at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Idiopathic mild platelet dysfunction was female\u2010predominant and showed spontaneous symptom resolution after a long follow\u2010up. Platelet function recovery was observed in most cases. Exogenous factors triggering this condition remain to be identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14433","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T12:19:03Z","timestamp":1738844343000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Idiopathic Mild Platelet Dysfunction: Baseline Characteristics and Clinical Courses"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8260-5319","authenticated-orcid":false,"given":"Nitchkan","family":"Wiwatsomwong","sequence":"first","affiliation":[{"name":"Center of Excellence in Translational Hematology, Division of Hematology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok 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