{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:37:55Z","timestamp":1776940675802,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dynamic monitoring of circulating tumor DNA (ctDNA) offers a non\u2010invasive method to track treatment response in malignancies. While well\u2010established in solid tumors, its role in lymphomas, especially in predicting response to CAR\u2010T cell therapy, remains underexplored\u2014more so in the Indian context. This case highlights ctDNA as a potential predictive biomarker in relapsed\/refractory DLBCL undergoing CAR\u2010T therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 48\u2010year\u2010old male with transformed follicular lymphoma to DLBCL, refractory to R\u2010CHOP and BR, was treated with anti\u2010CD19 CAR\u2010T cell therapy. Baseline ctDNA profiling from plasma revealed a TP53 p.E286K mutation at 1.3% VAF. Serial monitoring showed a decline to 0.4% at four weeks and complete clearance at eight weeks post\u2010infusion, correlating with metabolic complete response on PET\u2010CT. No co\u2010occurring mutations were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This case illustrates how dynamic ctDNA profiling can reflect early molecular response, preceding radiological confirmation. Existing literature suggests that early ctDNA negativity post\u2010CAR\u2010T correlates with improved outcomes. This is the first reported Indian case employing a validated, homebrew NGS\u2010based ctDNA assay to longitudinally track CAR\u2010T response. Incorporating ctDNA\u2010guided surveillance may refine response assessment and reduce unnecessary imaging, optimizing outcomes in resource\u2010constrained settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14503","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T01:59:58Z","timestamp":1748224798000},"page":"773-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic <scp>ctDNA<\/scp> Monitoring: A Primary Tool Predictive of Response in a Patient on <scp>CAR<\/scp>\u2010T Cell Therapy"],"prefix":"10.1111","volume":"47","author":[{"given":"Bhargava","family":"Rahul","sequence":"first","affiliation":[{"name":"Principal Director, Hematology and BMT Fortis Memorial Research Institute  Gurugram 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