{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:05:34Z","timestamp":1758045934876,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study examines the protein expression and mRNA levels of myeloperoxidase (MPO) in patients with Kikuchi's disease, and explores the association between the MPO\u2010463G\/A polymorphism and Kikuchi's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paraffin blocks from 43 patients with Kikuchi's disease were collected, and paraffin blocks from patients with reactive hyperplastic lymph nodes, granulomatous inflammation, and myeloid sarcoma were used as controls. Immunohistochemistry (IHC), quantitative reverse transcription polymerase chain Reaction (qRT\u2010PCR) and Sanger sequencing were used to detect the relevant variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive rate of MPO protein expression in the Kikuchi's disease group was 100% by IHC. In comparison to the control group, patients with Kikuchi's disease exhibited elevated <jats:italic>MPO<\/jats:italic> mRNA expression levels, which demonstrated a positive correlation with protein expression levels. Kikuchi's disease and reactive hyperplastic lymph nodes displayed distinct genotypes at the MPO\u2010463 locus, with mutation phenotypes of 7% and 30%, respectively. The G allele at this locus emerged as a risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Kikuchi's disease, both the protein and mRNA expression levels of MPO are elevated, and the high expression of mRNA is positively correlated with the protein expression levels. The polymorphism at the MPO\u2010463 locus may be associated with the occurrence of Kikuchi's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14509","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:43:27Z","timestamp":1752911007000},"page":"898-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Molecular Landscape of <scp>MPO<\/scp> in Kikuchi's Disease: Protein Expression, <scp>mRNA<\/scp> Levels, and Genetic Polymorphisms"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6043-0209","authenticated-orcid":false,"given":"Chen","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pathology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MengNa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shaanxi Provincial People's Hospital  Xi'an China"},{"name":"Department of Pathology Affiliated Hospital of Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Shaanxi Provincial People's Hospital  Xi'an China"},{"name":"Institute of Medical Research, Northwestern Polytechnical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","article-title":"Kikuchi\u2010Fujimoto Disease: A Rare Cause of Cervical Lymphadenopathy","volume":"13","author":"Ahmed Z.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199507000-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0219-RA"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"120","article-title":"Kikuchi\u2010Fujimoto Disease: A Clinicopathologic Update","volume":"108","author":"Pepe F.","year":"2016","journal-title":"Pathologica"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02418.x"},{"issue":"1","key":"e_1_2_10_7_1","article-title":"Kikuchi's Disease","volume":"140","author":"Alnaes M.","year":"2020","journal-title":"Tidsskrift for den Norske L\u00e6geforening"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14050"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2015.08.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0921-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065778"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.235341"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-017-1183-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390701286012"},{"issue":"3","key":"e_1_2_10_15_1","first-page":"217","article-title":"Meta\u2010Analysis of Myeloperoxidase Gene Polymorphism and Coronary Artery Disease Susceptibility","volume":"39","author":"Chen L.","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao. 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