{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:07:38Z","timestamp":1790654858576,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disseminated intravascular coagulation (DIC) is a critical complication in neonatal infections, necessitating early detection to reduce mortality. This study investigates the clinical utility of the tissue\u2010type plasminogen activator\u2010plasminogen activator inhibitor\u20101 complex (t\u2010PAIC) in assessing infection\u2010induced neonatal DIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis of 61 neonates with infections (July 2021\u2013February 2023) at West China Second University Hospital categorized patients into DIC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) and non\u2010DIC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938) groups using the Chinese DIC scoring system (CDSS). Univariate, multivariate, ROC, and Kaplan\u2013Meier analyses evaluated t\u2010PAIC levels, and a nomogram model was developed. A prospective study (March 2023\u2013January 2024) with 53 neonates validated the t\u2010PAIC threshold for DIC prediction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      t\u2010PAIC (OR\u2009=\u20091.332,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), thrombin time (TT) (OR\u2009=\u20092.317,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and aspartate aminotransferase (AST) (OR\u2009=\u20091.008,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) were independent DIC risk factors. t\u2010PAIC predicted DIC with an AUC of 0.783 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000), sensitivity of 0.652, and specificity of 0.816. A t\u2010PAIC threshold \u2265\u20098.85\u2009ng\/mL increased DIC risk and mortality (HR\u2009=\u20093.434,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). The nomogram combining t\u2010PAIC, TT, and AST showed superior predictive performance (AUC\u2009=\u20090.896, sensitivity\u2009=\u20090.826, specificity\u2009=\u20090.842). The prospective study confirmed t\u2010PAIC \u2265\u20098.85\u2009ng\/mL as a predictive marker for DIC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>t\u2010PAIC is an independent DIC risk factor in neonates with infections. A t\u2010PAIC level \u2265\u20098.85\u2009ng\/mL significantly increases DIC risk and mortality, highlighting its clinical utility in assessing infection\u2010induced neonatal DIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.14516","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:19:17Z","timestamp":1751663957000},"page":"1137-1146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Study on the Assessment of Infection\u2010Induced Disseminated Intravascular Coagulation (\n                    <scp>DIC<\/scp>\n                    ) and Its Prognosis in Neonates by Tissue\u2010Type Plasminogen Activator\u2010Plasminogen Activator Inhibitor\u20101 Complex"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6447-2310","authenticated-orcid":false,"given":"Xu","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-3028","authenticated-orcid":false,"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Second University Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Second University Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2023.04.020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010020\u20100815\u20107"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020350"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14578"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010364"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00340"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619852163"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910\u20101911TR"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00269.2021"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052721"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100864"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9364037"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911\u2010022\u201001836\u20103"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010020\u201003053\u2010y"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101713890"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101694995"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231195089"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101254050"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010021\u201000492\u20103"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1160\/th15\u201012\u20100964"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066618773679"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560\u2010023\u201000672\u20105"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa070"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010337"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221102929"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/mbc.0000000000001000"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214840"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613231190704"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041712"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101760332"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.166044"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/mbc.0000000000001197"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010021\u201003860\u20107"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2020.75.4.182"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010020\u201003327\u20101"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010022\u201004090\u20101"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094496"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2019"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010022\u201000510\u20108"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101229"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.14516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T03:33:16Z","timestamp":1762745596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.14516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ijlh.14516"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.14516","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}