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Therapeutic success depends on their timely and accurate recognition by hematology laboratory services. This review highlights the laboratory's role in identifying conditions associated with increased schistocytes (thrombotic microangiopathies) and acute promyelocytic leukemia. Their detection based on the routine laboratory and morphology methods should trigger appropriate additional laboratory workup including molecular tests, flow cytometry, etc. Hematology laboratory professionals should be skilled to recognize these emergencies and recommend additional workup, playing a critical role in the timely diagnosis and management of life\u2010threatening conditions.<\/jats:p>","DOI":"10.1111\/ijlh.14531","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:14:36Z","timestamp":1752718476000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Common Hematologic Emergencies\u2014Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias\u2014A Pivotal Role of Clinical Laboratory"],"prefix":"10.1111","volume":"48","author":[{"given":"Ganna","family":"Shestakova","sequence":"first","affiliation":[{"name":"University of Utah Department of Pathology  Salt Lake City Utah USA"},{"name":"ARUP Laboratories  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas Ulrich","family":"Edgar","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-162X","authenticated-orcid":false,"given":"Anton V.","family":"Rets","sequence":"additional","affiliation":[{"name":"University of Utah Department of Pathology  Salt Lake City Utah USA"},{"name":"ARUP Laboratories  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy165"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.02.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959\u2010018\u20100168\u20102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13682"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.138"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/MY70\u20107798\u20109KWD\u2010YP88"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12363"},{"key":"e_1_2_8_9_1","volume-title":"StatPearls","author":"Nu\u00f1ez Zuno J. 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