{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:49:19Z","timestamp":1774061359298,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cell Population Data (CPD), derived from next\u2010generation hematology analyzers, is emerging as a promising tool for diagnosis of early sepsis. This preliminary case\u2013control study assessed the diagnostic utility of CPD and its association with sequential organ failure assessment (SOFA) scores and procalcitonin levels in sepsis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010two sepsis patients and 72 age\u2010 and sex\u2010matched non\u2010septic controls were enrolled. CPD parameters were measured using a Sysmex XN\u20101000 analyzer. Univariate and multivariate analyses, including PCA, PLS\u2010DA, and OPLS\u2010DA, were used to distinguish between groups. ROC analysis evaluated diagnostic performance. Spearman's rank correlation assessed associations between CPD, SOFA scores, and procalcitonin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Several CPD parameters\u2014LY\u2010X, LY\u2010Z, MO\u2010X, MO\u2010Y, NE\u2010WX, NE\u2010WY, NE\u2010WZ, LY\u2010WX, LY\u2010WY, and LY\u2010WZ\u2014were significantly elevated in sepsis. Multivariate analysis identified MO\u2010X, MO\u2010WY, LY\u2010X, and LY\u2010Z as strong discriminators (VIP &gt;\u20091.15). ROC analysis showed MO\u2010X (&gt;\u2009119.6) had 95.83% sensitivity, 73.61% specificity (AUC 0.876), and IG% (&gt;\u20090.6) had 83.33% sensitivity, 80.56% specificity (AUC 0.880). IG count (&gt;\u200940\/\u03bcL) showed 81.94% sensitivity, 81.32% specificity (AUC 0.859); LY\u2010X (&gt;\u200979.3) had 93.06% sensitivity, 48.61% specificity (AUC 0.685); and MO\u2010WY (&gt;\u2009752) had 84.72% sensitivity, 45.83% specificity (AUC 0.597). SOFA score correlated with MO\u2010X (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), LY\u2010X (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and LY\u2010Z (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), while procalcitonin correlated with MO\u2010X (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and HFLC (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CPD is a promising, cost\u2010effective biomarker for diagnosis and severity assessment of sepsis, but inter\u2010equipment variability and current \u201cresearch use only\u201d status warrant further clinical validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.14539","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:01:41Z","timestamp":1755579701000},"page":"1054-1063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Cell Population Data for the Diagnosis and Assessment of Severity in Sepsis: A Preliminary Report"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-2173","authenticated-orcid":false,"given":"Priyanka","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Thosani","sequence":"additional","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Lab Sciences Command Hospital  Udhampur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-4904","authenticated-orcid":false,"given":"Preeti","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Lab Science Army Hospital, Research and Referral  New Delhi 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