{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:14:03Z","timestamp":1778253243074,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["56\/07\/22\u2010HAE\/BMS"],"award-info":[{"award-number":["56\/07\/22\u2010HAE\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The myeloma patients with baseline normal\/near\u2010normal serum free light chain (SFLC) ratio have been reported to respond favorably to the treatment, unlike patients with extreme\/abnormal SFLC ratio. We hypothesized that this normal SFLC ratio could serve as a biomarker for favorable cytogenetic and outcome profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The flow cytometric immunophenotyping (FCM\u2010IPT) and interphase FISH analysis of marrow aspirate were performed as per recommended guidelines, in all the newly diagnosed patients of plasma cell proliferative disorders, enrolled during this prospective study. Patients were risk\u2010stratified as per ISS, R\u2010ISS, and R2\u2010ISS criteria. The outcome evaluation, in patients treated with standard 3\u2010\/4\u2010drugs induction, was done at least 3\u2009months after initiation of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 306 patients with plasma cell proliferative disorders were enrolled; myeloma patients were 240 (\n                      <jats:italic>n_SFLC<\/jats:italic>\n                      \u2009=\u200923\/240, 9.6%) and (\n                      <jats:italic>ab_SFLC<\/jats:italic>\n                      \u2009=\u2009217\/240, 90.4%). IgG lambda M\u2010protein was more significantly seen in (\n                      <jats:italic>n_SFLC<\/jats:italic>\n                      ) patients. None of the patients in the (\n                      <jats:italic>n_SFLC<\/jats:italic>\n                      ) group showed circulating blood plasma cells. The (\n                      <jats:italic>n_SFLC<\/jats:italic>\n                      ) patients did not show the presence of\n                      <jats:italic>TP53<\/jats:italic>\n                      gene deletion and relatively lacked other high\u2010risk genetics. The outcome analysis showed that more patients in the (\n                      <jats:italic>n_SFLC<\/jats:italic>\n                      ) group attained \u2265\u2009VGPR (88.9% vs. 65.4% of\n                      <jats:italic>ab_SFLC<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on this, we infer that the patients with a normal SFLC ratio are enriched with non\u2010high\u2010risk features and behave less aggressively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70058","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:38:56Z","timestamp":1768822736000},"page":"598-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normal\n                    <scp>SFLC<\/scp>\n                    Ratio in Newly Diagnosed Myeloma: A Potential Biomarker of Non\u2010High\u2010Risk and Nonaggressive Disease"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-2656","authenticated-orcid":false,"given":"Manish K.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadav","family":"Sanjeev","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshita","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-2092","authenticated-orcid":false,"given":"Khaliqur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-6032","authenticated-orcid":false,"given":"Mona","family":"Vijayran","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poorvi","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan Sinha","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-8052","authenticated-orcid":false,"given":"Rajesh","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_159009"},{"key":"e_1_2_12_3_1","first-page":"105","article-title":"Screening Panels for Monoclonal Gammopathies: Time to Change","volume":"30","author":"Katzmann J. 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