{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:14:00Z","timestamp":1778253240718,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["I\u20101145"],"award-info":[{"award-number":["I\u20101145"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","award":["A\u2010193"],"award-info":[{"award-number":["A\u2010193"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","award":["A\u2010413"],"award-info":[{"award-number":["A\u2010413"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","award":["A\u2010600"],"award-info":[{"award-number":["A\u2010600"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n The B\u2010ALL risk\u2010stratification needs improvement. The prevalence and impact of Retinoblastoma 1, that is, RB transcriptional corepressor 1 (\n RB1<\/jats:italic>\n ) deletion in pediatric B\u2010ALL, alone and in concurrence with IKAROS family zinc finger 1 (\n IKZF1<\/jats:italic>\n ) deletion was estimated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Multiplex ligation\u2010dependent probe amplification (MLPA) was used to analyze the pediatric B\u2010ALL cases for gene deletions. The cases were divided into subgroups based on\n RB1<\/jats:italic>\n deletions and\n IKZF1<\/jats:italic>\n deletions. IKZF1plus profile (\n IKZF1<\/jats:italic>\n and additional\n CDKN2A\/B<\/jats:italic>\n ,\n PAX5<\/jats:italic>\n , pseudoautosomal region deletion in absence of\n ERG<\/jats:italic>\n deletion) was also noted.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In 517 patients with median age 7\u2009years (1\u201318), 41 (7.9%) had\n RB1<\/jats:italic>\n deletion and 99 (19.1%)\n IKZF1<\/jats:italic>\n deletion. Concurrent\n RB1<\/jats:italic>\n and\n IKZF1<\/jats:italic>\n deletions were 14 (2.7%),\n RB1<\/jats:italic>\n deletion without\n IKZF1<\/jats:italic>\n deletion 27 (5.2%),\n IKZF1<\/jats:italic>\n deletion without\n RB1<\/jats:italic>\n deletion 85 (16.4%), and none of\n RB1<\/jats:italic>\n or\n IKZF1<\/jats:italic>\n deletion 391 (75.6%). Of the treated patients (\n n<\/jats:italic>\n \u2009=\u2009465), cases with concurrent\n RB1<\/jats:italic>\n and\n IKZF1<\/jats:italic>\n deletions had the worst post\u2010induction remission rate (54.6%;\n p<\/jats:italic>\n \u2009=\u20090.019) compared to cases lacking\n RB1<\/jats:italic>\n or\n IKZF1<\/jats:italic>\n deletions (86%). The median event\u2010free and overall survival were poor in cases with concurrent\n RB1<\/jats:italic>\n and\n IKZF1<\/jats:italic>\n deletions (8.9\u2009months;\n p<\/jats:italic>\n \u2009=\u20090.0002 and 11.5\u2009months;\n p<\/jats:italic>\n \u2009=\u20090.007 respectively) compared to cases lacking\n RB1<\/jats:italic>\n or\n IKZF1<\/jats:italic>\n deletions (41.4\u2009months, and not reached respectively). The cases with\n RB1<\/jats:italic>\n deletion along with IKZF1plus profile had a trend of early deaths and relapses compared to IKZF1plus alone.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The B\u2010ALL patients with concurrent\n RB1<\/jats:italic>\n and\n IKZF1<\/jats:italic>\n deletions had worse outcomes compared to cases without any of these deletions. The\n RB1<\/jats:italic>\n deletion increased the risk of early events in patients with the IKZF1plus profile.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijlh.70069","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:21:15Z","timestamp":1770769275000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Retinoblastoma 1 (\n RB1<\/i>\n ) and\n IKZF1<\/i>\n Deletions Have Adverse Outcome in Childhood B\u2010Cell Acute Lymphoblastic Leukemia (B\u2010ALL)"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-0299","authenticated-orcid":false,"given":"Gadha","family":"Krishna Leons","sequence":"first","affiliation":[{"name":"Laboratory Oncology Unit, Dr BRA IRCH All India Institute of Medical Sciences (AIIMS) New Delhi 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