{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:14:03Z","timestamp":1778253243049,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Splenic B\u2010cell lymphoma\/leukemia includes a group of indolent small B\u2010cell lymphomas\/leukemias that share overlapping morphological and immunophenotypic features, making accurate diagnosis challenging. Specific gene rearrangements have not been commonly associated with splenic B\u2010cell lymphomas\/leukemias, and the\n TCL1<\/jats:italic>\n gene rearrangement\u2014characteristic of T\u2010cell prolymphocytic leukemia\u2014has not been previously reported in B\u2010cell lymphomas\/leukemias. Here, we report two unique cases of splenic B\u2010cell lymphoma\/leukemia harboring an\n IGH::TCL1<\/jats:italic>\n rearrangement.\n <\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n \n Patient #1 was a 74\u2010year\u2010old man with a 25\u2010year history of low\u2010grade B\u2010cell leukemia involving the peripheral blood, spleen, and bone marrow. Patent #2 was a 54\u2010year\u2010old woman who recently presented with lymphocytosis and low\u2010level bone marrow involvement. Both patients were asymptomatic and incidentally found to have lymphocytosis. The neoplastic cells in both cases displayed polar villous cytoplasmic projections, were of B\u2010cell lineage, and were negative for CD5 and CD10. Notably, an\n IGH::TCL1<\/jats:italic>\n fusion was identified in both cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The identification of\n IGH::TCL1<\/jats:italic>\n fusion in these two cases of splenic B\u2010cell lymphoma\/leukemia suggests that\n TCL1<\/jats:italic>\n gene rearrangements can occur in B\u2010cell lymphoma\/leukemia and should not be considered exclusive to T\u2010cell prolymphocytic leukemia. Accurate diagnosis of splenic B\u2010cell lymphoma\/leukemia with\n TCL1<\/jats:italic>\n rearrangement requires evaluation of morphologic and immunophenotypic features and genetic assessment of\n TCL1<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijlh.70082","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:03:23Z","timestamp":1772978603000},"page":"683-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Splenic B\u2010Cell Lymphoma\/Leukemia With\n \n TCL1<\/i>\n <\/scp>\n Gene Rearrangement"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9132-405X","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"Department of Pathology Albany Medical College Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_2_2_6_2_1","volume-title":"Hematolymphoid Tumors","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5GE1PSBMBZTW"},{"key":"e_1_2_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2015.10.019"},{"key":"e_1_2_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19754"},{"key":"e_1_2_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28060431"},{"key":"e_1_2_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15323"},{"key":"e_1_2_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201011\u2010751024"},{"key":"e_1_2_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160192"},{"key":"e_1_2_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201002\u2010267476"},{"key":"e_1_2_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1196813"},{"key":"e_1_2_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22821"},{"key":"e_1_2_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215455"},{"key":"e_1_2_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201009\u2010382838"},{"key":"e_1_2_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212410199"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.70082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:44:01Z","timestamp":1778251441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ijlh.70082"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.70082","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}