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Observations on LTA findings that are predictive of a bleeding disorder (including those specific to certain conditions) have been incorporated into guidelines to reduce LTA interpretation errors. Efforts to improve LTA assessment of PFD with thrombocytopenia (e.g., Bernard Soulier syndrome) have led to validated, trustworthy diagnostic procedures. Commonly encountered PFD that manifest with abnormal aggregation responses to multiple agonists and\/or DGD are now established to have significantly increased bleeding risks, emphasizing the need for diagnosis and treatment. Unraveling of the molecular pathogenesis of some specific PFD has provided important insights and simplified diagnosis. In the case of Quebec platelet disorder (QPD), the pathogenesis is a unique gain\u2010of\u2010function defect in fibrinolysis from a mutation that repositions a megakaryocyte\u2010specific enhancer that normally upregulates\n                      <jats:italic>VCL<\/jats:italic>\n                      expression during megakaryopoiesis and \u201crewires\u201d\n                      <jats:italic>PLAU<\/jats:italic>\n                      , increasing its expression &gt;\u2009100\u2010fold in megakaryocytes only. Presently, the molecular causes of many \u201ccommonly encountered\u201d PFD await elucidation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Research has meaningfully improved diagnostic laboratory testing for PFD. Unraveling the causes of \u201ccommonly encountered\u201d PFD will be important to understanding their pathogenesis and increasing the yield of diagnosis by genetic investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70110","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:00:31Z","timestamp":1776063631000},"page":"721-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigator\u2010Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-0817","authenticated-orcid":false,"given":"Catherine P. 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