{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:39:58Z","timestamp":1792381198198,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Fibrinogen deficiency is common in acute haemorrhage and requires prompt treatment to prevent exacerbation of coagulopathy. Conventional lab measurements are time consuming, leading to delayed intervention or empirical fibrinogen replacement, potentially exposing patients to unnecessary transfusion. The qLabs FIB system offers rapid point\u2010of\u2010care measurement of fibrinogen at the bedside; however, its use in patients taking Direct Oral Anticoagulants (DOACs) has not been evaluated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty patients chronically anticoagulated with Apixaban or Edoxaban undergoing catheter ablation procedures for atrial fibrillation were recruited. Citrated blood samples were taken from each patient and assessed using the qLab FIB system, and lab\u2010based Clauss assay (HemosIL Q.F.A. Thrombin (QFA), Werfen, Bedford, USA). DOAC levels were also measured, then removed using DOAC\u2010Remove (Quadratech, UK) to assess their impact. Statistical analysis was performed using Bland\u2013Altman, Passing\u2010Bablok regression and paired\n t<\/jats:italic>\n \u2010tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A strong linear correlation (\n r<\/jats:italic>\n \u2009=\u20090.88) was observed between the two methods; however, the qLabs FIB system consistently overestimated fibrinogen levels compared to the Clauss assay, with a mean bias of +0.50\u2009g\/L (95% LOA: \u22120.03 to +1.02\u2009g\/L). The Passing\u2010Bablok slope of 0.64 suggested that overestimation might be more pronounced at lower fibrinogen concentrations. DOAC presence did not significantly alter measurement results (\n p<\/jats:italic>\n \u2009=\u20090.380), and DOAC concentration did not correlate with the measurement discrepancy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The qLabs FIB system is a viable method for rapid assessment of fibrinogen levels in patients anticoagulated with DOACs. However, the presence of overestimation bias may have implications for clinical decision making.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijlh.70115","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:24:13Z","timestamp":1777530253000},"page":"1158-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Point\u2010Of\u2010Care Testing of Fibrinogen by the\n qLab FIB<\/scp>\n System in Patients Taking Direct Oral Anticoagulants (\n DOACs<\/scp>\n )"],"prefix":"10.1111","volume":"48","author":[{"given":"Christopher","family":"Long","sequence":"first","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Myers","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rodiera","sequence":"additional","affiliation":[{"name":"Centro Medico Teknon Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Falter","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1696946"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100031"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-017-0378-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004522"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-021-02987-9"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.03.018"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redare.2023.08.001"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000463"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001803"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes096"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-339-8_14"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaf155"},{"issue":"9","key":"e_1_2_13_14_1","first-page":"1439","article-title":"Effects of Freeze\u2010Thaw Times on Screening Coagulation Tests and Factors VIII and IX Activities in Citrate\u2010Anticoagulated Plasma at \u221220\u00b0C and \u221280\u00b0C","volume":"64","author":"Feng G.","year":"2018","journal-title":"Clinical Laboratory"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000184"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.70115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:55:06Z","timestamp":1792378506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ijlh.70115"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.70115","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}