{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:39:48Z","timestamp":1792381188546,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic myeloid leukemia (CML) is a disease characterized by Philadelphia (Ph) translocations. These translocations can be classical or variant. The structural features and diagnostic implications of variant Philadelphia translocations remain incompletely defined, and they display considerable cytogenetic heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, variant Ph translocations identified by conventional cytogenetic analysis and fluorescence in\u00a0situ hybridization (FISH) were systematically classified among 639 patients diagnosed with CML. A total of 35 patients with variant Ph translocations were included in the analysis. Molecular follow\u2010up data, when available, were assessed using RT\u2010qPCR analyses in a subset of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chromosome analysis revealed 2 simple and 33 complex variant Ph translocations. FISH analysis, performed in 20 patients, identified deletions involving\n                      <jats:italic>BCR<\/jats:italic>\n                      ,\n                      <jats:italic>ABL1<\/jats:italic>\n                      , or both in a limited number of cases. Additional chromosomal abnormalities and secondary translocations accompanied variant Ph translocations in four patients. The partner chromosomes involved in variant Ph translocations showed marked diversity, involving multiple chromosomal loci.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Variant Philadelphia chromosome translocations in CML exhibit substantial cytogenetic diversity, reflecting the complexity of their underlying genomic architecture. The rarity and heterogeneity of these rearrangements complicate their classification and interpretation in routine diagnostic practice. Descriptive reporting of variant Ph translocations may contribute to a better understanding of their diagnostic complexity and support more accurate cytogenetic interpretation in CML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70146","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:11:57Z","timestamp":1779192717000},"page":"1103-1112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytogenetic Diversity of Variant Philadelphia Translocations in Chronic Myeloid Leukemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-0632","authenticated-orcid":false,"given":"Ayse Gul Bayrak","family":"Tokac","sequence":"first","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Aday","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simge","family":"Erdem","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcin","family":"Bagatir","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Don","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozden","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akif Selim","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi Kalayoglu","family":"Besisik","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliha","family":"Nalcaci","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kivanc","family":"Cefle","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukru","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193575"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-328294"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2021.8795"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2005.08.024"},{"issue":"5","key":"e_1_2_12_7_1","first-page":"1181","article-title":"A Dual Colour Dual Fusion Fluorescence In\u00a0Situ Hybridisation Study on the Genesis of Complex Variant Translocations in Chronic Myelogenous Leukaemia","volume":"19","author":"So C. 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