{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:39:58Z","timestamp":1792381198986,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82200205"],"award-info":[{"award-number":["No.82200205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82200148"],"award-info":[{"award-number":["No.82200148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2025364"],"award-info":[{"award-number":["B2025364"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to characterize T follicular helper (Tfh) cell differentiation and related molecular profiles in chronic\u2010phase chronic myeloid leukemia (CML\u2010CP) patients with distinct molecular responses and to explore immune correlates of treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Peripheral blood CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells were analyzed in 125 CML\u2010CP patients (8 newly diagnosed, 71\u2009MMR, and 46 pre\u2010MMR) and 22 healthy donors. We assessed CD4\n                      <jats:sup>+<\/jats:sup>\n                      T subset distribution and expression of Tfh\u2010related molecules including Bcl6, Blimp1, PD\u20101, PD\u2010L1, and PD\u2010L2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Newly diagnosed and pre\u2010MMR patients exhibited decreased CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell proportions compared to healthy donors and MMR patients (\n                      <jats:italic>p\u2009&lt;\u20090.05<\/jats:italic>\n                      ), while pre\u2010MMR patients had elevated frequencies of CD4\n                      <jats:sup>+<\/jats:sup>\n                      CXCR5\n                      <jats:sup>+<\/jats:sup>\n                      PD\u20101\n                      <jats:sup>+<\/jats:sup>\n                      Tfh cells and increased PD\u20101 expression on CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells (\n                      <jats:italic>p\u2009&lt;\u20090.05<\/jats:italic>\n                      ). Bcl6, PD\u20101, and PD\u2010L1 were upregulated in pre\u2010MMR cases, whereas Blimp1 and PD\u2010L2 remained unaltered.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre\u2010MMR CML\u2010CP is accompanied by aberrant Tfh cell differentiation and an immunosuppressive immune signature linked to suboptimal molecular responses. Targeting immune checkpoints or modulating Tfh cell homeostasis may help improve therapeutic outcomes in CML\u2010CP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70160","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:07:51Z","timestamp":1780913271000},"page":"1133-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Tfh Cells and Related Molecules in\n                    <scp>CML<\/scp>\n                    \u2010\n                    <scp>CP<\/scp>\n                    Patients With Different Molecular Responses"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-0876","authenticated-orcid":false,"given":"Yulian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-0576","authenticated-orcid":false,"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingji","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilong","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0007"},{"key":"e_1_2_12_3_1","first-page":"353","article-title":"The Guidelines for Diagnosis and Treatment of Chronic Myelogenous Leukemia in China(2020 Edition)","volume":"41","author":"Chinese Society of Hematology, Chinese Medical Association","year":"2020","journal-title":"Chinese Journal of Hematology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61165-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11746"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609324"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.8899"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.134"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02074-w"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1473139"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235904"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1RI0121-066R"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021000"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101448"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.015"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0502"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.1906.1906"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06167-1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3122"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111874"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002865"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.007"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02374-0"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06199-x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669992"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113797"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055818"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-179697"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-06074-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029824"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.12.007"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34368"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153678"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101797"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-019-09090-y"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91487"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.70160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:56:09Z","timestamp":1792378569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ijlh.70160"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.70160","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2025-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}