{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:39:56Z","timestamp":1792381196831,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HemoScreen is an image\u2010based point\u2010of\u2010care (POC) hematology analyzer that performs complete blood counts (CBC) from small blood volumes with minimal handling. These features are particularly relevant in pediatrics; however, comparative evidence with central laboratory analyzers in children remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We compared HemoScreen POC with Sysmex XN\u20101000 analyzer in 141 venous K\n                      <jats:sub>2<\/jats:sub>\n                      \u2010EDTA samples from pediatric inpatients aged 2\u2009months\u201317\u2009years. The primary outcome was analytical agreement for white blood cells (WBC), red blood cells (RBC), and platelets (PLT). Secondary outcomes included: (1) analytical agreement for hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and mean platelet volume (MPV); and (2) diagnostic agreement for WBC, HGB, MCV, and PLT categories. Analytical agreement was evaluated using Passing\u2010Bablok regression, Bland\u2013Altman analysis, and proportions exceeding total allowable error (TEa) thresholds; Spearman's correlation was used to assess the strength of association between methods. Diagnostic agreement was quantified with Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      before and after Passing\u2010Bablok alignment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Correlations were strong to excellent, with no significant deviation from linearity. Mean biases were below the minimum acceptable limits for most parameters. Using the Passing\u2010Bablok regression as the reference line, the proportion of measurements exceeding limits was below 10% for WBC, RBC, PLT, and most other CBC indices in at least one of the tested TEa thresholds. Diagnostic agreement was excellent for leukopenia, leukocytosis, thrombocytopenia, anemia, and elevated HGB; good\u2010excellent for thrombocytosis and macrocytosis; and good for microcytosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In venous samples from pediatric inpatients (2\u2009months\u201317\u2009years), HemoScreen showed high analytical and diagnostic agreement with the Sysmex XN\u20101000, supporting its use in children's hospitals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70167","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:55:36Z","timestamp":1781088936000},"page":"1023-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemoscreen Point\u2010of\u2010Care Analyzer Compared With Sysmex XN\u20101000 for Complete Blood Count in Pediatric Inpatients Aged 2\u2009Months to 17\u2009Years"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-7806","authenticated-orcid":false,"given":"Alessio","family":"Correani","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Universit\u00e0 degli Studi di Padova  Padova Italy"},{"name":"Department of Odontostomatologic and Specialized Clinical Sciences Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Niccoletti","sequence":"additional","affiliation":[{"name":"SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Pavani","sequence":"additional","affiliation":[{"name":"SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Sampaolo","sequence":"additional","affiliation":[{"name":"SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Finaurini","sequence":"additional","affiliation":[{"name":"SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pelloso","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit University\u2010Hospital of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Montagnana","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit University\u2010Hospital of Padua  Padua Italy"},{"name":"Department of Medicine Universit\u00e0 degli Studi di Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Moretti","sequence":"additional","affiliation":[{"name":"SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria delle Marche  Ancona 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