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While CH is strongly linked to a spectrum of inflammatory diseases and hematologic malignancies, its role in shaping responses to cancer immunotherapy\u2014especially chimeric antigen receptor (CAR) T cell therapy\u2014has only recently begun to emerge. This review explores the interplay between CH and CAR T cell therapy, highlighting CH prevalence in treated populations, post\u2010therapy clonal dynamics, inflammatory toxicities, and risk of therapy\u2010related myeloid neoplasms. We also discuss the differential effects of specific CH mutations on hematopoiesis, immune cell function, and CAR T cell persistence. Understanding the functional implications of CH in the context of CAR T cell therapy holds the potential to refine patient selection, tailor toxicity management, and develop personalized immunotherapeutic approaches.<\/jats:p>","DOI":"10.1111\/ijlh.70181","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:57:06Z","timestamp":1782190626000},"page":"961-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clonal Hematopoiesis and\n                    <scp>CAR<\/scp>\n                    T Cell Therapy: From Biological Crosstalk to Clinical Implications"],"prefix":"10.1111","volume":"48","author":[{"given":"Wei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania 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