{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:39:20Z","timestamp":1786120760886,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize peripheral blood microRNA (miR)\u2010126 expression and evaluate its prognostic significance in patients with acute myeloid leukemia (AML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      AML patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978) and healthy volunteers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981) were enrolled in this retrospective study as the AML and Control groups. Clinical data were collected, and peripheral blood miR\u2010126 expression was measured by RT\u2010qPCR. Receiver operating characteristic (ROC) curves assessed the prognostic value of miR\u2010126. Kaplan\u2013Meier analysis compared survival outcomes between patients with high and low miR\u2010126 expression. Univariate and multivariate Cox regression analyses were conducted to determine whether miR\u2010126 was an independent risk factor for overall survival (OS) and progression\u2010free survival (PFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Peripheral blood miR\u2010126 expression was significantly higher in the AML group than in controls [1.30 (0.51\u20132.30) vs. 0.42 (0.30\u20130.62)]. The area under the ROC curve (AUC) of miR\u2010126 to distinguish AML patients from healthy controls was 0.815, with 62.82% sensitivity and 93.83% specificity at a cutoff value of 0.86. Patients with high miR\u2010126 expression had higher proportions of extramedullary infiltration and high\u2010risk European LeukemiaNet classification and significantly shorter OS and PFS. The AUC of miR\u2010126 for predicting poor prognosis was 0.796, with 73.20% sensitivity and 75.70% specificity at a cutoff value of 1.297. After adjustment, miR\u2010126 was confirmed as an independent predictor of reduced OS and PFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated peripheral blood miR\u2010126 expression is associated with reduced OS and PFS of patients with AML and may serve as a useful biomarker for prognostic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70211","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T01:20:46Z","timestamp":1786065646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Peripheral Blood\n                    <scp>microRNA<\/scp>\n                    \u2010126 and Its Prognostic Value in Patients With Acute Myeloid Leukemia"],"prefix":"10.1111","author":[{"given":"Haiying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated Ganzhou Hospital of Nanchang University  Ganzhou Jiangxi China"},{"name":"Jiangxi Health Commission Key Laboratory of Leukemia The Affiliated Ganzhou Hospital of Nanchang University  Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Ganzhou Hospital of Nanchang University  Ganzhou Jiangxi China"},{"name":"Jiangxi Health Commission Key Laboratory of Leukemia The Affiliated Ganzhou Hospital of Nanchang University  Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhou","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Ganzhou Hospital of Nanchang University  Ganzhou Jiangxi 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