{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:44:22Z","timestamp":1792025062335,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Morphological examination of bone marrow aspirates (BMA) remains essential for the diagnosis of hematologic diseases, but conventional microscopy is labor\u2010intensive and subject to interobserver variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 158 samples from patients were analyzed. Differential counts obtained by optical microscopy were compared with those of the CellaVision BMA Application used according to its intended workflow of automated preclassification followed by expert review. The two methods were compared by Pearson correlation, Passing\u2013Bablok regression, and Bland\u2013Altman analysis, both overall and within the blast and plasma cells intervals that bracket the diagnostic thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pearson correlation coefficients ranged from 0.85 to 0.99 for all populations except basophils (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.68). Passing\u2013Bablok regression showed no significant systematic or proportional bias for erythroblasts, granulocytic cells, eosinophils, and monocytes; a small systematic difference was observed for blasts, a small proportional difference for lymphocytes, and significant deviations from linearity for plasma cells and basophils. Bland\u2013Altman mean differences ranged from \u22121.4% to 1.2% across all populations. At the clinically relevant decision thresholds for blasts and plasma cells, overall agreement between the two methods ranged from 96.8% to 99.4%, although sensitivity at the 20% blast threshold was 77.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Used according to its intended workflow, the CellaVision BMA Application produced differential counts comparable with conventional microscopy for most nucleated cells, but agreement was weaker for basophils and plasma cells. Expert review and validation remain necessary. These findings, obtained in a single\u2010center series, provide a basis for further evaluation of this and similar systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.70263","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:49:50Z","timestamp":1792021790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance Evaluation of an Artificial Intelligence\u2010Assisted Digital Morphology System for Bone Marrow Aspirate Examination"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9165-2583","authenticated-orcid":false,"given":"S.","family":"Urrutia I\u00f1igo","sequence":"first","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-6587","authenticated-orcid":false,"given":"J. R.","family":"Furundarena Salsamendi","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-5915","authenticated-orcid":false,"given":"A.","family":"Uranga Aguirregomezcorta","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Agirrezabala Zurutuza","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arambarri Oyarzabal","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Uresandi Iruin","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Argoitia Ituarte","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6955-1148","authenticated-orcid":false,"given":"L.","family":"Urritza Manti\u00f1an","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Barbarin Echarri","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1514-9922","authenticated-orcid":false,"given":"C.","family":"Diez Sanz","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Carrasco Maceda","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Iranzo Alcazar","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Santa Catalina Nieto","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8631-9981","authenticated-orcid":false,"given":"C.","family":"Sarasqueta Eizaguirre","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epidemiology and Research Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-585X","authenticated-orcid":false,"given":"C.","family":"Panizo Santos","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia University Hospital  Donostia\u2010San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jcp.2005.035402","article-title":"Examination of Peripheral Blood Films Using Automated Microscopy; Evaluation of Diffmaster Octavia and CellaVision DM96","volume":"60","author":"Ceelie H.","year":"2007","journal-title":"Journal of Clinical Pathology"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1751-553X.2007.00996.x","article-title":"Performance Evaluation and Relevance of the CellaVision DM96 System in Routine Analysis and in Patients With Malignant Hematological Diseases","volume":"30","author":"Cornet E.","year":"2008","journal-title":"International Journal of Laboratory Hematology"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1751-553X.2007.01002.x","article-title":"Can Automated Blood Film Analysis Replace the Manual Differential? 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