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The purpose of this study was to report a quantitative systematic review of the effectiveness of calcium supplementation during pregnancy on reducing the risk of hypertensive disorders of pregnancy and related problems. Publications over the years of 1991\u20132012 were searched through<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed,<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cience<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>irect,<jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>eb of<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cience. The literatures were selected of the multicentre<jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>on calcium supplementation during pregnancy in prevention of hypertensive disorders and related problems. Reference lists from the studies were also examined for additional references. Studies were critically appraised by three independent reviewers, and the<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>andbook was used to assess the quality of those included trials. Four studies were included in this systematic review. All included studies were high quality, with low risk of bias. There was an observed risk reduction in hypertension in calcium group. However, there was no reduction in the risk of severe gestational hypertension, pre\u2010eclampsia, severe pre\u2010eclampsia, preterm birth and low birthweight. Calcium supplementation appears to reduce the risk of hypertension in pregnancy.<\/jats:p>","DOI":"10.1111\/ijn.12171","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T06:23:36Z","timestamp":1435386216000},"page":"19-31","source":"Crossref","is-referenced-by-count":12,"title":["Calcium supplementation reducing the risk of hypertensive disorders of pregnancy and related problems: A meta\u2010analysis of multicentre randomized controlled trials"],"prefix":"10.1111","volume":"21","author":[{"given":"Li\u2010bin","family":"An","sequence":"first","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010tao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie\u2010nan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Hospital of Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010hong","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010ning","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Nursing Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.03.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.05.027300"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.10.2202"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(83)90016-4"},{"key":"e_1_2_5_7_1","first-page":"317","article-title":"Calcium supplementation reduces blood pressure during pregnancy: Results of a randomized controlled clinical trial","volume":"70","author":"Villar J","year":"1987","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90091-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"237S","DOI":"10.1093\/ajcn\/54.1.237S","article-title":"Pregnancy\u2010induced hypertension and low birth weight: The role of calcium","volume":"54","author":"Repke JT","year":"1991","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90669-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111143252002"},{"issue":"3","key":"e_1_2_5_12_1","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems","author":"Atallah AN","year":"2000","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"e_1_2_5_13_1","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems","author":"Atallah AN","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001059.pub2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001059.pub3"},{"key":"e_1_2_5_16_1","unstructured":"World Health Organization.WHO recommendations for prevention and treatment of pre\u2010eclampsia and eclampsia. 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