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Demographic and clinical characteristics as well as disease\u2010specific health status (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">George's R<\/jats:styled-content>espiratory <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire, <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>) were assessed in 105 outpatients with advanced <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> at baseline and at 4, 8 and 12 months. Eighty\u2010five patients (81.0%) had complete <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> data at baseline and 12 months and were included in analyses. Stepwise multiple regression analysis revealed that lower <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> total score, higher depression scores and longer time needed to complete the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>imed <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>p and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>o (<jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>) test at baseline, as well as increase in time needed to complete the <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content> test and increase in dyspnoea during the 1\u2010year follow\u2010up period, were predictors of deterioration in disease\u2010specific health status. The current study reinforces the stimulation of physical mobility and the targeting of dyspnoea as components for treatment programs to optimize disease\u2010specific health status in patients with advanced <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijn.12265","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T10:53:05Z","timestamp":1395831185000},"page":"239-248","source":"Crossref","is-referenced-by-count":10,"title":["Determinants of 1\u2010year changes in disease\u2010specific health status in patients with advanced chronic obstructive pulmonary disease: A 1\u2010year observational study"],"prefix":"10.1111","volume":"21","author":[{"given":"Sarah","family":"Wilke","sequence":"first","affiliation":[{"name":"Program Development Centre CIRO+ (Centre of Expertise for Chronic Organ Failure)  Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn 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