{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:47:55Z","timestamp":1776185275271,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Nursing Practice"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To quantitatively analyse factors related to gastrointestinal bleeding after percutaneous coronary intervention and provide evidence for the prevention of gastrointestinal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources and Review Methods<\/jats:title><jats:p>Cochrane Library, Pubmed, Embase, and Ovid databases were searched from inception to 31 May 2018; case\u2010control and cohort studies published in English were included. The methodological quality of each study was assessed by two independent reviewers using the Newcastle\u2010Ottawa Scale. Meta\u2010analysis was performed using Revman version 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 publications yielded data about risk factors. It was found that age older than 70\u00a0years, age (per 10\u2010year increase), female sex, baseline anaemia, history of smoking, history of using alcohol, history of peptic ulcer disease, chronic renal failure, previous bleeding, shock, congestive heart failure, acute myocardial infarction, prior use of inotropic medications, and prior use of antithrombotic medications were positively associated with gastrointestinal bleeding. Four articles yielded data about protective factors. It was found that proton\u2010pump inhibitor and bivalirudin therapy were negatively associated with gastrointestinal bleeding after percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This research found risk and protective factors which can assist in effective management of this potentially fatal complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijn.12707","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T03:43:47Z","timestamp":1542685427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Meta\u2010analysis of risk and protective factors for gastrointestinal bleeding after percutaneous coronary intervention"],"prefix":"10.1111","volume":"25","author":[{"given":"Lan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Health Sciences of Wuhan University  Wuhan China"},{"name":"Department of Nursing, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajun","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Nursing, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-5944","authenticated-orcid":false,"given":"Yan\u2010Qiong","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Health Sciences of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Health Sciences of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.038"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007964"},{"issue":"18","key":"e_1_2_9_5_1","first-page":"1502","article-title":"Accf\/acg\/aha 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use","volume":"52","author":"Bhatt D. 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