{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:42:29Z","timestamp":1774737749853,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"crossref"}]},{"name":"New Balance Foundation"},{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"crossref","award":["TR001102"],"award-info":[{"award-number":["TR001102"]}],"id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["K24 DK082730"],"award-info":[{"award-number":["K24 DK082730"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence is lacking to recommend one diet over another when treating polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To obtain preliminary data, comparing the impact of a low\u2010glycaemic load (<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>) vs. low\u2010fat (<jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>) diet on biochemical hyperandrogenism in overweight and obese adolescents with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. To ascertain feasibility of recruiting study participants, in partnership with an adolescent clinic, and implementing dietary interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized controlled trial of 19 overweight and obese adolescents with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and not using hormonal contraceptives (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>). Interventions comprised nutrition education, dietary counselling and cooking workshops to foster adherence to a <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content> (45% carbohydrate, 35% fat, 20% protein) or <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> (55% carbohydrate, 25% fat, 20% protein) diet over 6 months. Serum bioavailable testosterone was the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen (<jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content>, <jats:italic>n<\/jats:italic>\u2009=\u20097; <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>, <jats:italic>n<\/jats:italic>\u2009=\u20099) participants completed the study. Body fat percentage decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in response to the interventions, with no difference between the <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> groups (\u22121.2% vs. \u22122.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.16). Bioavailable testosterone did not change for either group (\u22120.4 vs. \u22121.8\u2009ng\u2009dL<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.35). Regarding feasibility, recruiting adolescents posed a challenge, and use of <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content> was a main reason for ineligibility. Participants attended 5.9 of 6 in\u2010person visits and 2.6 of 3 cooking workshops, completed 4.9 of 6 telephone counselling calls, and reported high satisfaction with the diets and cooking workshops (\u22658 on a 10\u2010cm scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dietary interventions were beneficial for weight control but did not attenuate biochemical hyperandrogenism. Innovative strategies are needed to recruit adolescents for studies aimed at assessing independent effects of diet on features of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12047","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T13:36:53Z","timestamp":1435757813000},"page":"210-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents"],"prefix":"10.1111","volume":"11","author":[{"given":"J. M. W.","family":"Wong","sequence":"first","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children's Hospital  Boston MA USA"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gooding","sequence":"additional","affiliation":[{"name":"Division of Adolescent and Young Adult Medicine Boston Children's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Clinical Research Center Boston Children's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Divisions of Adolescent Medicine and Endocrinology Hasbro Children's Hospital  Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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