{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:20:53Z","timestamp":1783477253514,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Hypothalamic obesity (HyOb<\/jats:styled-content>) is a common complication of childhood hypothalamic tumours. Patients with HyOb<\/jats:styled-content> probably have a higher mortality rate than those with other types of obesity due in many cases to obstructive sleep apnoea\/hypoventilation.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To identify predictive factors for mortality caused by HyOb<\/jats:styled-content> in children.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty children with HyOb<\/jats:styled-content> secondary to hypothalamic tumours that were followed\u2010up for \u22653 years and aged <15 years at diagnosis, and received supraphysiological glucocorticoid treatment for \u22641 month.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age at diagnosis was 6.36\u2009\u00b1\u20093.60 years. Mean body mass index (BMI<\/jats:styled-content>) Standard deviation of the samples (SDS<\/jats:styled-content>) increased from 0.77\u2009\u00b1\u20091.26 to 2.66\u2009\u00b1\u20091.45 during the first 6 months, but slowed from month 6\u201312 (2.73\u2009\u00b1\u20091.35). \u0394BMI SDS<\/jats:styled-content> at 0\u20136 months was significantly higher in patients aged <6 years at diagnosis than in those aged >6 years at diagnosis (3.71\u2009\u00b1\u20091.96 vs. 0.83\u2009\u00b1\u20090.73, P<\/jats:italic>\u2009<\u20090.001). Maximum BMI SDS<\/jats:styled-content> was also significantly higher in the younger group (3.88\u2009\u00b1\u20091.39 vs. 2.79\u2009\u00b1\u20090.64, P<\/jats:italic>\u2009<\u20090.05). In all, four patients died and the mortality rate was significantly higher in the patients with a further increase in BMI SDS<\/jats:styled-content>\u2009>\u20091 SDS<\/jats:styled-content> after 6 months of therapy (RR<\/jats:styled-content>: 8.4, P<\/jats:italic>\u2009<\u20090.05). Both overall mortality and obesity\u2010related mortality rates were higher in the patients aged <6 years at diagnosis (4.5\u2010fold, 7.2\u2010fold higher, respectively, P<\/jats:italic>\u2009>\u20090.05). The mortality rate was also 3.7\u2010fold higher in the patients with a maximum BMI SDS<\/jats:styled-content>\u2009\u2265\u20093 at any time during the first 3 years after therapy(P<\/jats:italic>\u2009>\u20090.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>An increase in BMI SDS<\/jats:styled-content> after 6 months of therapy was observed to be a risk factor for mortality caused by HyOb<\/jats:styled-content>. In addition, age <6 years at diagnosis and a maximum BMI SDS<\/jats:styled-content>\u2009\u2265\u20093 were associated with a higher mortality rate, indicating that earlier and more aggressive treatment of obesity is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12076","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T09:23:05Z","timestamp":1444814585000},"page":"383-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Risk factors for mortality caused by hypothalamic obesity in children with hypothalamic tumours"],"prefix":"10.1111","volume":"11","author":[{"given":"B.","family":"Haliloglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Guran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Abal\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bereket","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Marmara University Medical School Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01004.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1115"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03838.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3525"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021180"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"T\u00fcrk \u00e7ocuklar\u0131nda v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, boy uzunlu\u011fu, ba\u015f \u00e7evresi ve v\u00fccut kitle indeksi referans de\u011ferleri","volume":"51","author":"Neyzi O","year":"2008","journal-title":"\u00c7ocuk Sa\u011f ve Hast Derg"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2006.19.2.121"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16855"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2817"},{"key":"e_1_2_6_11_1","first-page":"3897","article-title":"Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumour recurrence","volume":"11","author":"B\u00fclow B","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0859-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1210\/jcem.87.8.8751","article-title":"Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients","volume":"87","author":"M\u00fcller HL","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2013.00198.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.101089"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27129"},{"key":"e_1_2_6_17_1","first-page":"220","article-title":"Hypothalamic obesity: causes, consequences, treatment","volume":"6","author":"Lustig RH","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.11.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.PEDS11436"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3928"},{"key":"e_1_2_6_21_1","first-page":"19","article-title":"The evaluation of the influence of growth hormone therapy on growing process and metabolic functions in patients after treatment of craniopharyngioma","volume":"16","author":"Okonska M","year":"2010","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0667"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12076","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:55:40Z","timestamp":1696352140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,14]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ijpo.12076"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12076","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,14]]},"assertion":[{"value":"2015-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}