{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:19:01Z","timestamp":1793834341560,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Child Health and Human Development\/NIH Intramural Research Program","award":["ZIAHD000641"],"award-info":[{"award-number":["ZIAHD000641"]}]},{"name":"NIH Division of Nutrition Research Coordination, NIDDK, NIH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine associations of weight and adiposity with indices of thyroid function and thyroid\u2010related metabolic factors in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods<\/jats:title>\n                    <jats:p>\n                      A sample of 1203 children without obesity (body mass index [BMI]\u2009&lt;\u200995th percentile;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009631) and with obesity (BMI\u2009\u2265\u200995th percentile;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009572), age 5\u201318\u2009years, had height and weight measured (to calculate BMI\u2010Z score for age and sex) and had blood collected in the morning for thyroid\u2010stimulating hormone (TSH), free thyroxine (FT4) and leptin. A subset (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009829) also underwent measurement of fat mass by dual\u2010energy X\u2010ray absorptiometry. Analyses examined associations of TSH and FT4 with adiposity and obesity\u2010related conditions accounting for sociodemographic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thyroid\u2010stimulating hormone was positively related to BMIz and fat mass (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values\u2009&lt;\u20090.001). FT4 was negatively related to BMIz and fat mass (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values\u2009&lt;\u20090.001). TSH was positively correlated to leptin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) even after accounting for fat mass.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Paediatric obesity is associated with higher TSH and lower FT4 concentrations and with a greater prevalence of abnormally high TSH. Leptin concentrations may in part explain obesity's effects on thyroid status, perhaps through leptin's effects on TSH secretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.12112","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T23:25:45Z","timestamp":1456356345000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Associations between adiposity and indicators of thyroid status in children and adolescents"],"prefix":"10.1111","volume":"11","author":[{"given":"A. J.","family":"Krause","sequence":"first","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"},{"name":"NIH Division of Nutrition Research Coordination National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cines","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pogrebniak","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sherafat\u2010Kazemzadeh","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Demidowich","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. A.","family":"Galescu","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Radiology and Imaging Sciences Department, Hatfield Clinical Center, NIH  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"NIH Division of Nutrition Research Coordination National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Yanovski","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1245"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034979"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350348"},{"key":"e_1_2_7_5_1","volume-title":"Obesity","author":"Muscogiuri G","year":"2012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.140"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1118"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40631-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03877.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.04.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0095"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02526.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2798"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02433.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1169"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341363"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000284361"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0095"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000129678"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197872"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018815571892"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-10-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.4.320"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0180"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12148"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328344c393"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28589"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.320"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.12.10.0175"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00274.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/17477160600805006"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:14:39Z","timestamp":1696360479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/ijpo.12112"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12112","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]},"assertion":[{"value":"2015-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}