{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:52:25Z","timestamp":1762955545825},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Instituto de Salud Carlos III"},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["PI11\/02403"],"award-info":[{"award-number":["PI11\/02403"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Telomere length at birth is a major determinant of telomere length in late adulthood. However, the prenatal setting of telomere length is poorly understood. Individuals born large from non\u2010diabetic mothers are at lower risk for later\u2010life disorders than those born small, a feature of their longer health span being a higher lean mass that provides more muscle strength and that is already present in infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At birth, we studied leukocyte telomere length (by quantitative polymerase chain reaction) in 103 small\u2010for\u2010gestational\u2010age, appropriate\u2010for\u2010gestational\u2010age or large\u2010for\u2010gestational\u2010age (SGA, AGA or LGA) infants born after uncomplicated, term, singleton pregnancies. All infants were breastfed for \u22654\u2009months. At 2\u2009weeks and 12\u2009months, body composition was assessed by dual X\u2010ray absorptiometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Telomere lengths were shorter in SGA newborns and longer in LGA newborns than in AGA newborns (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), also after adjustment for maternal age, pre\u2010gestational body mass index, gestational weight gain and gestational age. Telomere length at birth associated (all <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001) to birthweight (<jats:italic>r<\/jats:italic>\u2009=\u20090.50) and to both lean mass (<jats:italic>r<\/jats:italic>\u2009=\u20090.43) and fat mass (<jats:italic>r<\/jats:italic>\u2009=\u20090.48) at age 2\u2009weeks, but only to lean mass at 12\u2009months (<jats:italic>r<\/jats:italic>\u2009=\u20090.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher weight and longer telomeres at birth are followed by more lean mass in late infancy. Relatively large, breastfed infants from non\u2010diabetic mothers may become models of how to make a healthy start.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12137","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T07:13:36Z","timestamp":1460531616000},"page":"274-279","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Recognition of a sequence: more growth before birth, longer telomeres at birth, more lean mass after birth"],"prefix":"10.1111","volume":"12","author":[{"given":"F.","family":"de Zegher","sequence":"first","affiliation":[{"name":"Department of Development &amp; Regeneration University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP\u2010HSJD) University of Barcelona  Esplugues, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lopez\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dr. Josep Trueta Hospital  Girona Spain"},{"name":"Girona Institute for Biomedical Research  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP\u2010HSJD) University of Barcelona  Esplugues, Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM)  Madrid 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