{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:19:18Z","timestamp":1780373958551,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of excess weight on cardiovascular disease risk in type 1 diabetes patients is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined associations of BMI and body composition with cardiovascular risk factors in youth followed prospectively for 18\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample includes youth with type 1 diabetes (N\u2009=\u2009136, baseline age\u2009=\u200912.3\u2009\u00b1\u20092.5y, glycated hemoglobin\u2009=\u20098.1\u2009\u00b1\u20091.1%) participating in an 18\u2010month behavioral nutrition intervention trial. BMI, body composition (by dual energy x\u2010ray absorptiometry), total cholesterol (TC), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C); triglycerides (TG), c\u2010reactive protein (CRP), 8\u2010iso\u2010prostaglandin\u2010F2alpha (8\u2010iso\u2010PGF2\u03b1), adiponectin and systolic and diastolic blood pressure (SBP and DBP, respectively) were assessed at clinic visits every 6\u2009months. Random effects regression models for repeated measures estimated associations of time\u2010varying BMI and body composition with time\u2010varying cardiovascular risk factors, adjusted for treatment assignment and covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no intervention effect on cardiovascular risk factors. Percent body fat was positively associated with TG, LDL\u2010C, CRP, SBP and DBP, while trunk fat mass and trunk %fat were associated positively with TG, LDL\u2010C, CRP, SBP and DBP, and inversely with HDL\u2010C. Higher BMI was associated with greater TG, CRP, SBP and DBP and lower HDL\u2010C. BMI and body composition indicators were unrelated to 8\u2010iso\u2010PGF2\u03b1 and adiponectin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Excess adiposity is associated with increased cardiovascular risk factors in this sample of youth with type 1 diabetes. Non\u2010significant associations with adiponectin and 8\u2010iso\u2010PGF2\u03b1 suggest potential differences from the general population in the role of adiposity in cardiovascular health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12167","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T13:52:10Z","timestamp":1468590730000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-4388","authenticated-orcid":false,"given":"LM","family":"Lipsky","sequence":"first","affiliation":[{"name":"Health Behavior Branch, Division of Intramural Population Health Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  North Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gee","sequence":"additional","affiliation":[{"name":"Health Behavior Branch, Division of Intramural Population Health Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  North Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Liu","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TR","family":"Nansel","sequence":"additional","affiliation":[{"name":"Health Behavior Branch, Division of Intramural Population Health Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  North Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0862"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001321"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.727"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000094"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1720"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00519.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.171016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2239"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.7.567"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.12.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.077487"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.7.1084"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.01.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E-167"},{"key":"e_1_2_8_17_1","first-page":"240","article-title":"Blood pressure in children and adolescents with type 1 diabetes mellitus\u2010\u2010the influence of body mass index and fat mass","volume":"15","author":"Pietrzak I","year":"2009","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0785-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00469.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.068"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm125"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12159"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-015-0214-4"},{"key":"e_1_2_8_24_1","first-page":"1","article-title":"Changes in terminology for childhood overweight and obesity","author":"Ogden CL","year":"2010","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_8_25_1","unstructured":"Centers for Disease Control and Prevention.Behavioral Risk Factor Surveillance System Survey Questionnaire. 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