{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:35:46Z","timestamp":1785897346302,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL002942"],"award-info":[{"award-number":["HL002942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL015103"],"award-info":[{"award-number":["HL015103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD032194"],"award-info":[{"award-number":["HD032194"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG016592"],"award-info":[{"award-number":["AG016592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG041200"],"award-info":[{"award-number":["AG041200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD069587"],"award-info":[{"award-number":["HD069587"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult obesity is associated with infertility; however, childhood obesity has received little consideration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study sought to evaluate the impact of childhood adiposity on fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Associations between childhood adiposity and self\u2010reported fertility difficulties were estimated among women participating in a long\u2010term study of cardiovascular risks and reproductive health (<jats:italic>n<\/jats:italic>\u2009=\u20091061).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with obesity between ages 9 and 12 were more likely to report fertility difficulties (adjusted relative risk [aRR], 1.82, 95% CI 1.17\u20132.82) and inability to become pregnant when trying (aRR\u2009=\u20091.94, 95% CI 1.22\u20133.08) as were those with obesity prior to age 9 (aRR\u2009=\u20091.76, 95% CI 1.04\u20132.97). Similar associations were seen among those ever overweight or obese in childhood. High subscapular skinfold thickness (age\u2009&lt;\u200912) increased risk of receiving help becoming pregnant (aRR\u2009=\u20092.16, 95% CI 1.15\u20134.06), inability to become pregnant (aRR\u2009=\u20091.46, 95% CI 1.05\u20132.04) and any fertility difficulties (aRR\u2009=\u20091.56, 95% CI 1.13\u20132.14); associations for triceps skinfold were attenuated. Participants with increased adiposity also had fewer pregnancies and live births. Effects persisted, excluding women with polycystic ovarian syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports an association between childhood adiposity and infertility, not solely driven by polycystic ovarian syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12168","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T08:29:21Z","timestamp":1467188961000},"page":"477-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Childhood adiposity and fertility difficulties: the Bogalusa Heart Study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-6692","authenticated-orcid":false,"given":"M. B.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Epidemiology Tulane University School of Public Health and Tropical Medicine  New Orleans USA"},{"name":"Department of Biostatistics and Study Methodology, Children's National Health System Children's Research Institute  Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Tulane University School of Public Health and Tropical Medicine  New Orleans USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pridjian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tulane University School of Medicine  New Orleans USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. W.","family":"Harville","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Tulane University School of Public Health and Tropical Medicine  New Orleans USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32825e1d70"},{"key":"e_1_2_7_3_1","first-page":"107","article-title":"Impact of obesity on gynecology","volume":"6","author":"Pandey S","year":"2010","journal-title":"Womens Health"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136582"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328236743f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00990.x"},{"key":"e_1_2_7_7_1","first-page":"57","article-title":"The association of obesity with infertility and related menstural abnormalities in women","volume":"3","author":"Hartz AJ","year":"1979","journal-title":"Int J Obes (Lond)"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.4.886"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181257158"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90465-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800424"},{"key":"e_1_2_7_12_1","volume-title":"Cardiovascular Risk Factors in Children: The Early Natural History of Atherosclerosis and Essential Hypertension","author":"Berenson GS","year":"1980"},{"key":"e_1_2_7_13_1","unstructured":"Centers for Disease Control and Prevention National Center for Health Statistics.Data table of BMI\u2010for\u2010age charts: females 2\u201320\u2009years.http:\/\/www.cdc.gov\/growthcharts\/html_charts\/bmiagerev.htm. 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