{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:51:05Z","timestamp":1783104665022,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Children with obesity have low spontaneous growth hormone (GH) secretion. High circulating free fatty acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults, lipolytic inhibition with niacin lowers FFA and increases GH, but there are no prior studies in children with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to determine the dose and frequency of niacin administration required to lower FFA and stimulate GH in children with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Dose\u2010finding study of nondiabetic children ages 6\u201312\u2009years with body mass index (BMI)\u2009\u2265\u200995th percentile given niacin 250\u2009mg q2h\u2009\u00d7\u20093 doses (<jats:italic>n<\/jats:italic>\u2009=\u20092), 500\u2009mg q2h\u2009\u00d7\u20093 doses (<jats:italic>n<\/jats:italic>\u2009=\u20095) or 500\u2009mg q1h\u2009\u00d7\u20094 doses (<jats:italic>n<\/jats:italic>\u2009=\u20095).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eight boys and four girls (age 9.7\u2009\u00b1\u20091.8\u2009years; BMI 26.4\u2009\u00b1\u20093.1\u2009kg\u2009m<jats:sup>\u22122<\/jats:sup>; BMIz 2.2\u2009\u00b1\u2009.25) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome<\/jats:title><jats:p>Percentage of serum FFA values that were below 0.2\u2009mEq\u2009L<jats:sup>\u22121<\/jats:sup>. GH, insulin and glucose were also measured serially.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FFA decreased as the dose and frequency of niacin increased (<jats:italic>p<\/jats:italic>\u2009=\u2009.01). Niacin 500\u2009mg q1h 4 doses suppressed FFA\u2009&lt;\u20090.2\u2009mEq\u2009L<jats:sup>\u22121<\/jats:sup> and significantly increased GH (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). Adverse effects were flushing\/warmth (100%), tingling (60%) and GI complaints (20\u201340%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Niacin 500\u2009mg q1h significantly lowered serum FFA and increased GH. These pilot data suggest that high FFA is an important suppressor of GH secretion in children with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12184","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T21:38:42Z","timestamp":1474493922000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A pilot study of the effects of niacin administration on free fatty acid and growth hormone concentrations in children with obesity"],"prefix":"10.1111","volume":"13","author":[{"given":"O. A.","family":"Galescu","sequence":"first","affiliation":[{"name":"Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)  Bethesda USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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