{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:03:53Z","timestamp":1789646633240,"version":"4.0.0"},"reference-count":28,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The predisposition for obesity is suggested to originate in the prenatal period. Prenatal markers are needed to identify foetuses at risk for neonatal adiposity, as early marker of childhood obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to assess the association between foetal fractional thigh volume (TVol) and neonatal percentage fat mass from mid\u2010gestation onward.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this perinatal cohort study, singleton pregnancies with term born infants were included. Foetal TVol was measured on three\u2010dimensional ultrasound scans (3D US) obtained at 22, 26 and 32\u00a0weeks of gestation. Neonatal body composition measurement (percentage body fat (%BF)) was planned between 42<jats:sup>+0<\/jats:sup> and 42<jats:sup>+6<\/jats:sup>\u2010week postmenstrual age. Cross\u2010sectional and longitudinal linear regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine mother\u2013child pairs were included. Median (interquartile range) TVol increased from 7.6 (7.1; 8.5) cm<jats:sup>3<\/jats:sup> at 22\u00a0weeks to 36.5 (33.8; 40.9) cm<jats:sup>3<\/jats:sup> at 32\u00a0weeks. Median neonatal %BF was 14.3% (11.7; 17.0). TVol at 22\u00a0weeks (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22121.58, 95% CI \u22122.45; \u22120.70, explained variance 31%) was negatively associated with %BF, but no associations were found at 26 and 32\u00a0weeks of gestation. TVol growth between 22 and 32\u00a0weeks of gestation (explained variance 18%) was also statistically significantly negatively associated with %BF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Foetal TVol is a promising 3D US marker for prediction of neonatal adiposity from mid\u2010gestation onward.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12231","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:43:24Z","timestamp":1501231404000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Foetal fractional thigh volume: an early 3D ultrasound marker of neonatal adiposity"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-9398","authenticated-orcid":false,"given":"J. A.","family":"Roelants","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. V.","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A. L.","family":"Groenenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Biostatistics Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. S.","family":"Hokken\u2010Koelega","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. F. M.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Intensive Care Unit Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P. M.","family":"Steegers\u2010Theunissen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology Erasmus MC\u2013Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17477160600586689"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21323"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30098-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.09.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.109058"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6319"},{"key":"e_1_2_10_9_1","article-title":"Association of ultrasound\u2010based measures of fetal body composition with newborn adiposity","author":"Ikenoue S","year":"2016","journal-title":"Pediatr Obes"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.06028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1779"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv147"},{"key":"e_1_2_10_13_1","unstructured":"EUROCAT Guide 1.4 Chapter 3.3http:\/\/www.eurocat\u2010network.eu\/content\/EUROCAT\u2010Guide\u20101.4\u2010Section\u20103.3.pdf.September 2014 accessed."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.90"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000049669.74793.E3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(87)90099-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5225"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980615)17:11<1261::AID-SIM846>3.0.CO;2-Z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0389-2"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360417"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14042"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441298"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/35.5.1169"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000239767"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.09086"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv472"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T12:33:07Z","timestamp":1695645187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":28,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ijpo.12231"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12231","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]},"assertion":[{"value":"2017-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}