{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:18:41Z","timestamp":1787681921229,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010381","name":"European Society for Paediatric Endocrinology","doi-asserted-by":"publisher","award":["ESPE Research Unit Grant Award"],"award-info":[{"award-number":["ESPE Research Unit Grant Award"]}],"id":[{"id":"10.13039\/100010381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008316","name":"Baden-W\u00fcrttemberg Stiftung","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/100008316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The liver\u2010specific miR\u2010122 was proposed as biomarker for NAFLD in adults. Here, we investigated the relationship between miR\u2010122 levels, parameters of liver metabolism and NAFLD in pre\u2010pubertal obese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parameters of liver metabolism (ALT, AST and GGT) of three European cohorts were included (German cohort [<jats:italic>n<\/jats:italic>\u00a0=\u00a071; age: 11.53\u00a0\u00b1\u00a01.29\u00a0years; BMI z\u2010score: 2.96\u00a0\u00b1\u00a00.64], Italian cohort [<jats:italic>n<\/jats:italic>\u00a0=\u00a045; age: 9.60\u00a0\u00b1\u00a02.11\u00a0years; BMI z\u2010score: 3.57\u00a0\u00b1\u00a01.16], Slovenian cohort [<jats:italic>n<\/jats:italic>\u00a0=\u00a031; age: 7.53\u00a0\u00b1\u00a01.47\u00a0years; BMI z\u2010score: 3.66\u00a0\u00b1\u00a00.88]). MiR\u2010122 levels and CK18 concentrations were measured in fasting blood samples. In the German and Italian cohort, the diagnosis of NAFLD and grading of NAFLD was assessed by ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NAFLD was diagnosed in <jats:italic>n<\/jats:italic>\u00a0=\u00a050 patients of the German cohort (29.6%) and in <jats:italic>n<\/jats:italic>\u00a0=\u00a029 patients (72.5%) of the Italian cohort. In all three cohorts, miR\u2010122 was positively correlated with ALT and AST as well as with CK18 concentrations. MiR\u2010122 levels were higher in children with NAFLD compared with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MiR\u2010122 levels in pre\u2010pubertal obese children could be a potential biomarker for paediatric NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12261","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:58:45Z","timestamp":1514077125000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Circulating levels of miR\u2010122 and nonalcoholic fatty liver disease in pre\u2010pubertal obese children"],"prefix":"10.1111","volume":"13","author":[{"given":"S.","family":"Brandt","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine University Medical Center Ulm  Ulm 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