{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:08:02Z","timestamp":1790104082533,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK090126"],"award-info":[{"award-number":["K01DK090126"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL105349"],"award-info":[{"award-number":["T32HL105349"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR00165"],"award-info":[{"award-number":["UL1TR00165"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK056336"],"award-info":[{"award-number":["P30DK056336"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK090126"],"award-info":[{"award-number":["K01DK090126"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK079626"],"award-info":[{"award-number":["P30DK079626"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cord blood adiponectin and leptin concentrations are associated with birth weight and adiposity. Birth size and rate of infant weight gain are associated with future obesity risk. However, it is unclear whether biomarkers reflecting the intrauterine environment are predictive of infant prospective body composition change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine whether cord blood adiponectin and leptin are predictive of neonatal adiposity and fat mass (FM) accrual to 3\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) were healthy African American infants. Leptin and adiponectin concentrations were measured in umbilical cord blood. At 2\u00a0weeks and 3\u00a0months, infant body composition was assessed via air displacement plethysmography. Weight\u2010for\u2010length z\u2010scores (WLZ) were calculated using World Health Organization standards. Multiple linear regression was used to examine associations of cord blood adiponectin and leptin with birth WLZ; WLZ, FM and fat\u2010free mass at 2\u00a0weeks, and the conditional change in these variables from 2\u00a0weeks to 3\u00a0months (body composition at 3\u00a0months adjusted for body composition at 2\u00a0weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adiponectin was positively associated with FM at 2\u00a0weeks (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.45, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), but inversely associated with conditional FM change from 2\u00a0weeks to 3\u00a0months of age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.38, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Leptin was not significantly associated with infant body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adiponectin may be a marker for FM accrual in African American infants, a relatively understudied population with a high long\u2010term obesity risk. Mechanistic studies are needed to determine whether adiponectin directly influences infant growth or is simply a maker reflective of other ongoing biological changes after birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12274","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T08:27:52Z","timestamp":1521880072000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Associations of neonatal adiponectin and leptin with growth and body composition in African American infants"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4659-5858","authenticated-orcid":false,"given":"C. R.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Center for Reproductive Health\/MetroHealth Medical Center  Cleveland OH USA"},{"name":"Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Biggio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Center for Women's Reproductive Health University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"Gower","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Chandler\u2010Laney","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.3.429"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12204"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20481"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000142711.24999.8A"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02041.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078085"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0343"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.07.052"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0431"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03521.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12248"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3534-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0061-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181da901a"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2100"},{"key":"e_1_2_7_20_1","unstructured":"Prevention CfDCa.National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States 2014. 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