{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:15:44Z","timestamp":1779927344543,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the effects of obesity on myocardial mechanics and ventriculo\u2010arterial coupling (V\u2010A) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Strain parameters, stroke volume, arterial elastance, left ventricular (LV) elastance and V\u2010A were compared after adjusting for age and hypertension and after multivariate sub\u2010group analysis between patients with and without obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 123 retrospectively enrolled subjects, 6\u201321\u00a0years age, 79.7% males, 52% were obese. Median (range) Body Mass Index Z score was +2.35 (1.67\u20134.43) for obese and +0.68 (\u22122.48\u20131.63) for non\u2010obese. Subjects with obesity had higher LV mass indexed<jats:sup>2.7<\/jats:sup> (LVMI<jats:sup>2.7<\/jats:sup>) compared with non\u2010obese (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Lower global longitudinal strain (GLS) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012), global circumferential strain (GCS) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), average longitudinal strain rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and average circumferential strain rate (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were seen in subjects with obesity; no difference was noted in arterial elastance, LV end systolic elastance and V\u2010A. Increased LVMI<jats:sup>2.7<\/jats:sup>, decreased GLS, GCS, average longitudinal strain rate, average circumferential strain rate and maintained V\u2010A were noted in the multivariate analysis between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity causes alterations in myocardial mechanics with preserved V\u2010A in children. These findings may aid intervention in preventing the long\u2010term cadiovascular effects of obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12278","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T05:04:33Z","timestamp":1521781473000},"page":"541-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Left ventricular remodelling and vascular adaptive changes in adolescents with obesity"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-6931","authenticated-orcid":false,"given":"A.","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Icahn School of Medicine, Bronx Lebanon Hospital Center  Bronx USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gulesserian","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Pediatric Heart Center of Vienna Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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