{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:35Z","timestamp":1791946115431,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["Flagship Project Epigen,Interomics and Elixir\u2010IIB"],"award-info":[{"award-number":["Flagship Project Epigen,Interomics and Elixir\u2010IIB"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children born small for gestational age (SGA) are at increased risk of metabolic dysfunction. Dysregulation of specific microRNAs (miRNAs) contributes to aberrant gene expression patterns underlying metabolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine and compare circulating miRNA (c\u2010miRNA) profile of SGA and appropriate for gestational age (AGA) children with obesity and with normal weight, in order to identify biomarkers for early detection of increased risk of developing metabolic dysfunction in SGA and AGA children with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Small non\u2010coding RNAs from serum of 15 SGA children with obesity (OB\u2010SGA), 10 SGA children with normal weight (NW\u2010SGA), 17 AGA children with obesity (OB\u2010AGA) and 12 AGA children with normal weight (NW\u2010AGA) (mean age 11.2\u00a0\u00b1\u00a02.6) have been extracted and sequenced in order to detect and quantify miRNA expression profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RNA\u2010seq analyses showed 28 miRNAs dysregulated in OB\u2010SGA vs. NW\u2010SGA and 19 miRNAs dysregulated in OB\u2010AGA vs. NW\u2010AGA. Among these, miR\u201092a\u20103p, miR\u2010122\u20105p, miR\u2010423\u20105p, miR\u2010484, miR\u2010486\u20103p and miR\u2010532\u20105p were up regulated, and miR\u2010181b\u20105p was down regulated in both OB\u2010SGA and OB\u2010AGA compared with normal weight counterparts. Pathway analysis and miRNA target prediction suggested that these miRNAs were particularly involved in insulin signalling, glucose transport, insulin resistance, cholesterol and lipid metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a specific profile of c\u2010miRNAs in SGA and AGA children with obesity compared with SGA and AGA children with normal weight. These c\u2010miRNAs could represent specific biomarkers for early detection of increased risk of developing metabolic dysfunction in SGA and AGA children with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12439","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T10:12:07Z","timestamp":1535623927000},"page":"803-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age"],"prefix":"10.1111","volume":"13","author":[{"given":"F.","family":"Marzano","sequence":"first","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies\u2010IBIOM, CNR  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Faienza","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Pediatrics University of Bari \u201cA. Moro,\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Caratozzolo","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies\u2010IBIOM, CNR  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neuroscience, and Sense Organs, Section of Human Anatomy and Histology University of Bari \u201cA. Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chiara","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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M.","family":"D'Erchia","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies\u2010IBIOM, CNR  Bari Italy"},{"name":"Department of Bioscience, Biotechnology and Biopharmaceutics University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Consiglio","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Technologies of Bari \u2013 ITB, National Research Council  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pesole","sequence":"additional","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies\u2010IBIOM, CNR  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sbis\u00e0","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Technologies of Bari \u2013 ITB, National Research Council  Bari 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