{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:25:26Z","timestamp":1782408326040,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1T32HD069038\u201005"],"award-info":[{"award-number":["1T32HD069038\u201005"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with obesity are more likely to suffer gastroesophageal reflux disease, requiring acid\u2010suppression therapy with proton pump inhibitors (PPIs) and no guidelines regarding dosing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To prospectively evaluate lean\u2010body\u2010weight\u2010based (LBW) dosing of the PPI pantoprazole for children with and without obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methods: Sixty\u2010two children (6\u201317 years) received a one\u2010time oral dose of liquid pantoprazole (1.2 mg kg<jats:sup>\u22121<\/jats:sup> LBW). Plasma pantoprazole concentrations were measured at 10 time points over 8 h and pharmacokinetic (PK) profiles generated using non\u2010compartmental techniques, in order to compare PK parameters of interest between children with and without obesity, while accounting for <jats:italic>CYP2C19<\/jats:italic> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted for milligram\u2010per\u2010kilogram total body weight (TBW) pantoprazole received, apparent drug clearance (CL\/F) was reduced 50% in children with vs. without obesity (p=0.03).  LBW\u2010based dosing compensated for this reduction in CL\/F (<jats:italic>p<\/jats:italic> = 0.15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To achieve comparable systemic PPI exposures for children with and without obesity, we recommend using LBW, rather than TBW\u2010based dosing for pantoprazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12459","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T19:10:25Z","timestamp":1537989025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-648X","authenticated-orcid":false,"given":"V.","family":"Shakhnovich","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"},{"name":"Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation The Childrens Mercy Hospital  Kansas City MO USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition The Childrens Mercy Hospital  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Abdel\u2010Rahman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"},{"name":"Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation The Childrens Mercy Hospital  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition The Childrens Mercy Hospital  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Weigel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Leeder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri Kansas City School of Medicine  Kansas City MO USA"},{"name":"Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation The Childrens Mercy Hospital  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Kearns","sequence":"additional","affiliation":[{"name":"Section of Clinical Pharmacology and Toxicology Arkansas Childrens Hospital  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"06","article-title":"Prevalence of childhood and adult obesity in the United States","volume":"311","author":"Ogden CL","year":"2013","journal-title":"JAMA Pediatr"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/17477166.2010.491118"},{"key":"e_1_2_6_4_1","first-page":"23","article-title":"Gastroesophageal reflux disease: could intervention in childhood reduce the risk of later complications?","author":"Gold B","year":"2004","journal-title":"Am J Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.064"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12475"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80457-N"},{"key":"e_1_2_6_10_1","unstructured":"Gene\u2010specific information tables for CYP2C19. PharmGKB and CPIC. Stanford University2017.https:\/\/www.pharmgkb.org\/page\/cyp2c19RefMaterials. 11 Jan 2017"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T20:27:14Z","timestamp":1694723234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/ijpo.12459"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12459","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"2018-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12459"}}