{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:50:54Z","timestamp":1760550654945},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["119504","115707"],"award-info":[{"award-number":["119504","115707"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Physical activity is associated with improved cardiometabolic markers in children with nonsyndromic obesity (NSO). Prader\u2013Willi Syndrome (PWS) is a neurodevelopmental disorder characterized by obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare cardiometabolic changes in response to a home\u2010based parent\u2010facilitated physical activity intervention between children with PWS or with NSO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 18 children with PWS (age\u00a0=\u00a010.5\u00a0\u00b1\u00a00.7y; body fat\u00a0=\u00a044.6\u00a0\u00b1\u00a02.0%) and 30 children with NSO (age\u00a0=\u00a09.7\u00a0\u00b1\u00a00.2y; body fat\u00a0=\u00a044.8\u00a0\u00b1\u00a01.2%). Active Play @ Home was a 24\u2010week physical activity intervention curriculum containing playground\u2010based and active video games completed 4\u00a0days per week. Pre\u2010 and post\u2010intervention measurements included physical activity, body composition, blood samples analysed for glucose, insulin, lipids and cytokines, and insulin resistance computed using the homeostatic model of assessment for insulin resistance (HOMA\u2010IR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All children (<jats:italic>n<\/jats:italic>\u00a0=\u00a048) showed a significant decrease in Interleukin\u20108 (3.64\u00a0\u00b1\u00a00.24 vs. 3.06\u00a0\u00b1\u00a00.22\u00a0pg\/mL). Children with obesity who did not gain or who lost body fat percentage (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) demonstrated a significant decrease in HOMA\u2010IR (3.17\u00a0\u00b1\u00a00.39 vs. 2.72\u00a0\u00b1\u00a00.34) and an increase in high\u2010density lipoprotein (44.30\u00a0\u00b1\u00a02.51 vs. 47.29\u00a0\u00b1\u00a02.59\u00a0mg\/dL). All other measurements showed no significant changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most favourable changes in cardiometabolic factors were observed in children with nonsyndromic obesity who demonstrated no gain or a decrease in body fat percentage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12462","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T23:00:11Z","timestamp":1537225211000},"page":"734-743","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in cardiometabolic markers in children with Prader\u2013Willi syndrome and nonsyndromic obesity following participation in a home\u2010based physical activity intervention"],"prefix":"10.1111","volume":"13","author":[{"given":"D. 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