{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:36:23Z","timestamp":1791855383207,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15GRNT25880008"],"award-info":[{"award-number":["15GRNT25880008"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K99\/R00HL130580\u201002"],"award-info":[{"award-number":["K99\/R00HL130580\u201002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2R01HL088530\u201010"],"award-info":[{"award-number":["2R01HL088530\u201010"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99\/R00HL130580\u201002"],"award-info":[{"award-number":["K99\/R00HL130580\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01HL088530\u201010"],"award-info":[{"award-number":["2R01HL088530\u201010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While the genetic contribution to obesity is well established, few studies have examined how genetic variants influence standardized body mass index <jats:italic>Z<\/jats:italic>\u2010score (BMIz) in Hispanics\/Latinos, especially across childhood and adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We estimated the effect of established BMIz loci in Chilean children of the Santiago Longitudinal Study (SLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined associations with BMIz at age 10 for 15 loci previously identified in European children. For significant loci, we performed association analyses at ages 5 and 16\u00a0years, for which we have smaller sample sizes. We tested associations of unweighted genetic risk scores (GRSs) for previously identified tag variants (GRS_EUR) and from the most significant variants in SLS at each locus (GRS_SLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We generalized five variants at age 10 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 and directionally consistent), including rs543874 that reached Bonferroni\u2010corrected significance. The effect on BMIz was greatest at age 10 for all significant loci, except <jats:italic>FTO<\/jats:italic>, which exhibited an increase in effect from ages 5 to 16. Both GRSs were associated with BMIz (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), but GRS_SLS explained a much greater proportion of the variation (13.63%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results underscore the importance of conducting genetic investigations across life stages and selecting ancestry appropriate tag variants in future studies for disease prediction and clinical evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12479","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T06:09:36Z","timestamp":1543990176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-8712","authenticated-orcid":false,"given":"A.E.","family":"Justice","sequence":"first","affiliation":[{"name":"Biomedical and Translational Informatics Geisinger  Danville PA USA"},{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chittoor","sequence":"additional","affiliation":[{"name":"Biomedical and Translational Informatics Geisinger  Danville PA USA"},{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Division of Academic General Pediatrics, Child Development and Community Health at the Center for Community Health University of California, San Diego  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Albala","sequence":"additional","affiliation":[{"name":"Department of Public Health Nutrition, Institute of Nutrition and Food Technology (INTA) University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Angel","sequence":"additional","affiliation":[{"name":"Department of Public Health Nutrition, Institute of Nutrition and Food Technology (INTA) University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lozoff","sequence":"additional","affiliation":[{"name":"Pediatrics and Communicable Diseases University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.S.","family":"Voruganti","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Nutrition Research Institute University of North Carolina at Chapel Hill  Kannapolis NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gahagan","sequence":"additional","affiliation":[{"name":"Division of Academic General Pediatrics, Child Development and Community Health at the Center for Community Health University of California, San Diego  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62037-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2013.01.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.190"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001283"},{"key":"e_1_2_7_7_1","unstructured":"Ministry of Health G.o.C.ENCUESTA NACIONAL DE SALUD 2016\u20132017: Primeros resultados.2017[cited 2018 March 23]; 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