{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:11:51Z","timestamp":1778580711472,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["115707"],"award-info":[{"award-number":["115707"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["119504"],"award-info":[{"award-number":["119504"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The roles of obestatin and adropin in paediatric obesity are poorly understood. We compared obestatin and adropin concentrations in younger (n\u00a0=\u00a021) and older children (n\u00a0=\u00a014) with Prader\u2010Willi syndrome (PWS) and age and BMI\u2010z\u2010matched controls (n\u00a0=\u00a031). Fasting plasma obestatin and adropin were higher in younger children with PWS than controls; adropin was also higher in older children with PWS. Growth hormone treatment had no effects on obestatin or adropin in PWS. The ratio of ghrelin to obestatin declined from early to late childhood but was higher in older PWS than older controls. Adropin correlated with fasting glucose in the PWS group only. Changes in the ratio of ghrelin to obestatin may suggest changes in the processing of preproghrelin to ghrelin and obestatin during development and differential processing of preproghrelin in PWS.<\/jats:p>","DOI":"10.1111\/ijpo.12493","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T15:59:14Z","timestamp":1545926354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Obestatin and adropin in Prader\u2010Willi syndrome and nonsyndromic obesity: Associations with weight, BMI\u2010z, and HOMA\u2010IR"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-0528","authenticated-orcid":false,"given":"C. E.","family":"Orsso","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-0170","authenticated-orcid":false,"given":"A. A.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine, Saint Louis University  St. Louis Missouri United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-0706","authenticated-orcid":false,"given":"M. J.","family":"Muehlbauer","sequence":"additional","affiliation":[{"name":"Sarah W. Stedman Nutrition and Metabolism Center Duke University Medical Center  Durham North Carolina United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Cui","sequence":"additional","affiliation":[{"name":"Sarah W. Stedman Nutrition and Metabolism Center Duke University Medical Center  Durham North Carolina United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-8251","authenticated-orcid":false,"given":"D. A.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Kinesiology California State University  Fullerton California United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-9135","authenticated-orcid":false,"given":"M.","family":"Pakseresht","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-0524","authenticated-orcid":false,"given":"M. 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