{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:30:39Z","timestamp":1768343439022,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI15\/01078"],"award-info":[{"award-number":["PI15\/01078"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI17\/01455"],"award-info":[{"award-number":["PI17\/01455"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>S100A4 is a marker of subcutaneous adipose tissue dysfunction. Polycystic ovary syndrome (PCOS) is often driven by hepato\u2010visceral adiposity. PCOS phenotypes are normalized more by reduction of central fat with spironolactone\/pioglitazone\/metformin (SPIOMET) than by oral contraceptive (OC) treatment. We studied whether circulating S100A4 concentrations are high in adolescents with PCOS and, if so, whether they normalize more with OC or SPIOMET. Assessments included circulating S100A4, endocrine markers, body composition, abdominal fat partitioning in controls (n\u00a0=\u00a012) and girls with PCOS (n\u00a0=\u00a051; age 15.8\u00a0y; body mass index [BMI] 24.5\u00a0kg\/m<jats:sup>2<\/jats:sup>), and 1\u2010year changes in girls with PCOS randomized for OC (n\u00a0=\u00a027) or SPIOMET (n\u00a0=\u00a024) treatment. Mean S100A4 concentrations were 71% higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in girls with PCOS than in controls and associated with hepato\u2010visceral adiposity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.47; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001); S100A4 concentrations decreased more (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) with SPIOMET, those decreases associating to hepato\u2010visceral fat loss (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.50; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). S100A4 may become a circulating marker of hepato\u2010visceral fat excess in adolescents with PCOS.<\/jats:p>","DOI":"10.1111\/ijpo.12500","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T20:16:52Z","timestamp":1547756212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Towards a circulating marker of hepato\u2010visceral fat excess: S100A4 in adolescent girls with polycystic ovary syndrome \u2014 Evidence from randomized clinical trials"],"prefix":"10.1111","volume":"14","author":[{"given":"Rita","family":"Malpique","sequence":"first","affiliation":[{"name":"Endocrinology, Pediatric Research Institute Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Network Biomedical Research Center of Diabetes and Associated Metabolic Disorders (CIBERDEM) Health Institute Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"S\u00e1nchez\u2010Infantes","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Germans Trias i Pujol Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garcia\u2010Beltran","sequence":"additional","affiliation":[{"name":"Endocrinology, Pediatric Research Institute Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Network Biomedical Research Center of Diabetes and Associated Metabolic Disorders (CIBERDEM) Health Institute Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri D.","family":"Taxer\u00e5s","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Germans Trias i Pujol Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel","family":"L\u00f3pez\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Hospital Dr. Josep Trueta &amp; Girona Institute for Biomedical Research  Girona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"de Zegher","sequence":"additional","affiliation":[{"name":"Department of Development &amp; Regeneration University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-7191","authenticated-orcid":false,"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Endocrinology, Pediatric Research Institute Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Network Biomedical Research Center of Diabetes and Associated Metabolic Disorders (CIBERDEM) Health Institute Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.7.1086"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803997200"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1400-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0191-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0018-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.58"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3886"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2017.04.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21935"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.198"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479371"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0067-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017547108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012608"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3967"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy091"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21917"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijpo.12500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:01:30Z","timestamp":1694390490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/ijpo.12500"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12500","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"2018-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12500"}}