{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:55:49Z","timestamp":1772776549262,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI08\/0443"],"award-info":[{"award-number":["PI08\/0443"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI11\/02403"],"award-info":[{"award-number":["PI11\/02403"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance and hepato\u2010visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche\/pubarche and puberty\/menarche; this earlier timing in turn relates often to a mismatch between prenatal and postnatal weight gain, which can be estimated by calculating the Z\u2010score change from birth weight (BW) to body mass index (BMI) in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato\u2010visceral adiposity in prepuberty by reappraising a cohort of children (mean age, 8.5\u00a0years), born appropriate\u2010 (AGA, n\u00a0=\u00a041) or small\u2010for\u2010gestational age (SGA, n\u00a0=\u00a045), followed since birth (n\u00a0=\u00a076) or since the age of 3 years (n\u00a0=\u00a010). Assessments included anthropometry; fasting glucose and insulin; liver volume; and hepatic fat, subcutaneous fat, and visceral fat in the abdominal region (by magnetic resonance imaging [MRI]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Z\u2010score change BW\u2010BMI closely associated to central fat (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.74; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and insulin resistance (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.71; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that Z\u2010score change BW\u2010BMI could be viewed as a simple candidate\u2010marker for hepato\u2010visceral adiposity and insulin resistance in prepubertal children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12533","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T10:08:55Z","timestamp":1560247735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Towards a simple marker of hepato\u2010visceral adiposity and insulin resistance: The Z\u2010score change from weight\u2010at\u2010birth to BMI\u2010in\u2010childhood"],"prefix":"10.1111","volume":"14","author":[{"given":"Francis","family":"de Zegher","sequence":"first","affiliation":[{"name":"Department of Development &amp; Regeneration University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Malpique","sequence":"additional","affiliation":[{"name":"Endocrinology Pediatric Research Institute Sant Joan de D\u00e9u, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garcia\u2010Beltran","sequence":"additional","affiliation":[{"name":"Endocrinology Pediatric Research Institute Sant Joan de D\u00e9u, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Endocrinology Pediatric Research Institute Sant Joan de D\u00e9u, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.127"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031848"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1378"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.198"},{"key":"e_1_2_8_7_1","volume-title":"Patrones de crecimiento y desarrollo en Espa\u00f1a","author":"Ferr\u00e1ndez\u2010Long\u00e1s A","year":"2004"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijpo.12533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:34:00Z","timestamp":1694259240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/ijpo.12533"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12533","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"assertion":[{"value":"2018-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12533"}}