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Relationships of maternal early pregnancy (15\u00a0weeks' gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      28.1% of mothers were classified as overweight and 10.1% with obesity; compared with normal weight mothers, the BFP of their children were 5.3% higher (0.16 SD [95% CI, 0.04\u20100.29]\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) and 7.8% higher (0.27 [0.08\u20100.47]\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006) with comparable values for BMI z\u2010score and arm, waist, and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child's SST, BMI z\u2010score, hip circumference, and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this contemporary large prospective cohort study with extensive maternal\/childhood phenotyping and a high prevalence of maternal overweight\/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity; similar associations were observed with PlGF, which may imply a role for placenta function in the developmental programming of childhood obesity risk.<\/jats:p>\n                  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