{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:16:47Z","timestamp":1768720607947,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD033487"],"award-info":[{"award-number":["R01HD033487"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL088530"],"award-info":[{"award-number":["R01HL088530"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL117860"],"award-info":[{"award-number":["R01HL117860"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polyunsaturated fatty acids (PUFA) have been related to the development of adiposity. N\u20103 PUFA appears to be protective against obesity risk, while n\u20106 PUFA may be associated with greater adiposity. However, most studies have been conducted among adults. The role of PUFA in infancy is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine associations of serum PUFA at age 1 year with age\u2010 and sex\u2010adjusted body mass index Z score (BMIZ) change through age 16\u2009years and body composition at 16\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We quantified serum PUFA in 636 Chilean infants aged 1 year. We measured BMIZ at ages 1, 5, 10 and 16\u2009years, and body composition by dual energy X\u2010ray absorptiometry at 16\u2009years. We estimated differences in 1\u2010 to 16\u2010years BMIZ change between PUFA quartiles from multivariable linear mixed models with restricted cubic splines. At 16\u2009years, we estimated differences in total fat mass (ToFM), truncal fat mass (TrFM), total lean mass (TLM), percent total fat mass (%ToFM) and percent truncal fat mass (%TrFM) between PUFA quartiles using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PUFA were not associated with BMIZ change. Alpha\u2010linolenic acid (ALA) was positively associated with TrFM (<jats:italic>P<\/jats:italic> = .03) and %TrFM (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) at 16\u2009years while eicosapentaenoic acid (EPA) was inversely associated with %TrFM (<jats:italic>P<\/jats:italic> = .001). Docosapentaenoic acid (DPA) was positively associated with ToFM (<jats:italic>P<\/jats:italic> = .01), TrFM (<jats:italic>P<\/jats:italic> = .009), %ToFM (<jats:italic>P<\/jats:italic> = .02) and %TrFM (<jats:italic>P<\/jats:italic> = .02). Gamma\u2010linolenic acid (GLA) and the \u03946\u2010desaturase (D6D) activity index were each positively, linearly associated with ToFM, TrFM and %ToFM. The \u03945\u2010desaturase (D5D) activity index was inversely associated with %TrFM (<jats:italic>P<\/jats:italic> = .04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ALA, DPA, GLA and the D6D index at 1 year of age were positively associated with adiposity at age 16\u2009years, while EPA and the D5D index were inversely associated with central adiposity. Our results related to EPA and desaturase indices are in agreement with limited prior studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12656","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:04:37Z","timestamp":1589886277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum polyunsaturated fatty acids in infancy are associated with body composition in adolescence"],"prefix":"10.1111","volume":"15","author":[{"given":"Kerry","family":"Flannagan","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Gahagan","sequence":"additional","affiliation":[{"name":"Division of Child Development and Community Health University of California  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-0689","authenticated-orcid":false,"given":"Raquel","family":"Burrows","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Lozoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-5574","authenticated-orcid":false,"given":"Eduardo","family":"Villamor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01015.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32129-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00584.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442945"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835c1ba7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451200150X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2016.06.003"},{"key":"e_1_2_9_9_1","first-page":"Cd011094","article-title":"Omega\u20106 fats for the primary and secondary prevention of cardiovascular disease","volume":"11","author":"Hooper L","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_10_1","volume-title":"Modern Nutrition in Health and Disease","author":"Shils ME","year":"2006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2016.04.011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a605"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06902"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.05.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.128215"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-8-23"},{"issue":"1","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3945\/ajcn.112.042267","article-title":"Long\u2010chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development","volume":"97","author":"Merwe LF","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980010003678"},{"issue":"4","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1542\/peds.112.4.846","article-title":"Behavioral and developmental effects of preventing iron\u2010deficiency anemia in healthy full\u2010term infants","volume":"112","author":"Lozoff B","year":"2003","journal-title":"Pediatrics"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.3.683"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980015001585"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D007534"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)40190-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0890"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"issue":"3","key":"e_1_2_9_28_1","first-page":"243","article-title":"Scale for measurement of socioeconomic level, in the health area","volume":"113","author":"Alvarez ML","year":"1985","journal-title":"Rev Med Chil"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.141"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.56"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080504"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008002322"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2307\/1912934"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.112847"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005801"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2762"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508993521"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02540558"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapol\/czt034"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.79"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2623"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61794-3"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm026"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0175-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000252"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2013.10.001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0764-7"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.167270"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-014-0418-1"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2693"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.12476"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-07320-0_7"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1247-0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2008.03.003"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228646"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi187"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601962"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001283"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.083790"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijpo.12656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijpo.12656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.12656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:01:39Z","timestamp":1693890099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.12656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/ijpo.12656"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.12656","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2019-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12656"}}