{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:48:36Z","timestamp":1787806116678,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoantibodies are frequently positive in adults with nonalcoholic fatty liver disease (NAFLD) without concurrent autoimmune hepatitis (AIH). The clinical significance of this is unknown in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of autoantibody positivity in pediatric NAFLD and to evaluate its association with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter, retrospective study of patients \u226418\u2009years of age with biopsy\u2010confirmed NAFLD. Descriptive statistics were used and groups were compared using Wilcoxon\u2010Mann Whitney or \u03c7<jats:sup>2<\/jats:sup> testing, and multivariable logistic regression was used for binary or ordinal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty six patients with a median age of 14\u2009years were included. The median body mass index <jats:italic>Z<\/jats:italic>\u2010score was 2.5 (interquartile range 2.2, 2.6). Positive antinuclear antibody (ANA), anti\u2010smooth muscle antibody (ASMA), anti\u2010liver\u2010kidney microsomal antibody, or any combination of autoantibodies were observed in 22%, 14%, 0%, and 33% of patients, respectively. The proportion of patients with a steatosis score \u22652 was significantly higher in those with positive ANA (<jats:italic>P<\/jats:italic> =\u2009.045). In the multivariable regression analysis, positive ANA was associated with increased odds of steatosis score \u22652 (odds ratio, 5.91; 95% confidential interval, 1.50\u201023.26), after controlling for potential confounders. No other significant histology differences were seen between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive ANA and ASMA are common in children with NAFLD; however, anti\u2010LKM positivity is not. ANA positivity is associated with more severe steatosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12696","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T07:00:15Z","timestamp":1594191615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Significance of autoantibody seropositivity in children with obesity and non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Toshifumi","family":"Yodoshi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Orkin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catalina","family":"Arce\u2010Clachar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Bramlage","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavra A.","family":"Xanthakos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialena","family":"Mouzaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-2004","authenticated-orcid":false,"given":"Pamela L.","family":"Valentino","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Pediatrics Yale University School of Medicine  New Haven 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