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The associations of abdominal adiposity derived from dual\u2010energy X\u2010ray absorptiometry (DXA), including VAT, subcutaneous abdominal adipose tissue (SAAT) and total abdominal adipose tissue (TAAT) with cardio\u2010metabolic risk in adolescents are understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined the cross\u2010sectional associations of DXA\u2010measured abdominal adiposity with cardio\u2010metabolic risk and related markers in early adolescence (mean [SD] age 13.0 [0.7] years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data from 740 adolescents (374 girls and 366 boys) in Project Viva, a U.S. pre\u2010birth cohort. We used DXA estimates of VAT, SAAT and TAAT area. We conducted overall and sex\u2010stratified linear regression models, adjusting for age, sex (in overall models), race\/ethnicity, puberty score and body mass index (BMI) <jats:italic>z<\/jats:italic>\u2010score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean BMI <jats:italic>z<\/jats:italic>\u2010score was 0.59 (1.28). After adjustment, greater VAT (per 1 SD score) was associated with higher metabolic risk <jats:italic>z<\/jats:italic>\u2010score (\u03b2 0.14\u2009units; 95% CI 0.08, 0.20), higher log high\u2010sensitivity C\u2010reactive protein (\u03b2 0.51\u2009mg\/L; 0.36, 0.66) and log leptin (\u03b2 0.36\u2009ng\/mL; 0.27, 0.44), and lower log adiponectin (\u03b2 \u22120.08 ug\/mL; \u22120.13, \u22120.02). SAAT and TAAT showed similar associations as VAT with comparable or greater effect sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In early adolescence, DXA\u2010measured VAT, SAAT and TAAT are associated with cardio\u2010metabolic risk and related markers, independent of current BMI. Among two adolescents with the same BMI, there is an associated higher cardio\u2010metabolic risk in the adolescent with greater DXA\u2010measured abdominal adiposity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12704","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T07:45:06Z","timestamp":1596699906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Associations of <scp>DXA<\/scp>\u2010measured abdominal adiposity with cardio\u2010metabolic risk and related markers in early adolescence in Project Viva"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-5439","authenticated-orcid":false,"given":"Allison J.","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsie M.","family":"Taveras","sequence":"additional","affiliation":[{"name":"Division of General Academic Pediatrics Massachusetts General Hospital for Children  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675355"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.372"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.4.465"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3246"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70175-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.6.833"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.8.1515"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021267"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.5.453"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2014.218.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.138"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.393"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.249"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"85","article-title":"Anthropometric indices as measures of body fat assessed by DXA in relation to cardiovascular risk factors in children and adolescents: NHANES 1999\u20102004","volume":"11","author":"Cui Z","year":"2015","journal-title":"Int J Body Compos Res"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-017-0236-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20519"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20223"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20424"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2019.1638967"},{"key":"e_1_2_9_22_1","unstructured":"Child growth standards: BMI\u2010for\u2010age. 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